Clinical significance of MASP-2 and complement factor H in patients with autoimmune hepatitis
Objective To analyze the relationships between the levels of mannose associated serine protease 2(MASP-2)and complement factor H and the severity and recurrence of autoimmune hepatitis.Methods A retrospective analysis was conducted on the clinical data of 60 patients with autoimmune hepatitis treated in Yan'an People's Hospital from February 2020 to February 2021.They were selected as the observation group,consisting of 17 males and 43 females,with an age of(52.71±3.58)years old.According to the Child-Pugh grading system,they were divided into grade A group(26 cases),grade B group(22 cases),and grade C group(12 cases).Additionally,based on the 1-year follow-up results,they were divided into a recurrent group(15 cases)and a non-recurrent group(45 cases).A total of 60 healthy individuals who underwent physical examinations in Yan'an People's Hospital during the same period were selected as the control group,with 13 males and 47 females,with an age of(52.64±3.62)years old.t test or repeated measure analysis of variance was used to compare the MASP-2 and complement factor H levels among different groups.Spearman correlation analysis was used to analyze the correlations between MASP-2 and complement factor H levels and Child-Pugh grading.The value of MASP-2 and complement factor H levels in predicting recurrence in patients with autoimmune hepatitis was analyzed by receiver operating characteristic curve(ROC).Results The levels of MASP-2 and complement factor H in the observation group were(91.89±15.74)μg/L and(66.28±12.58)mg/L,which were lower than those in the control group[(262.93±35.63)μg/L and(145.31±25.71)mg/L],with statistically significant differences(t=31.013 and 21.387,both P＜0.001).The levels of MASP-2 and complement factor H in grade A and B groups were(106.72±16.52)μg/L,(84.94±14.73)μg/L,(76.87±12.46)mg/L,and(61.66±9.38)mg/L,which were higher than those in group C[(72.80±12.59)μg/L and(52.12±8.89)mg/L],and those in group A were higher than those in group B,with statistically significant differences(all P＜0.05).The levels of MASP-2 and complement factor H in the recurrent group were(78.30±13.66)μg/L and(56.20±8.53)mg/L,which were lower than those in the non-recurrent group[(96.48±15.57)μg/L and(69.61±7.36)mg/L],with statistically significant differences(t=4.030 and 5.893,both P＜0.001).Spearman correlation analysis showed that the MASP-2 and complement factor H levels were negatively correlated with Child-Pugh grading(r=-0.721 and-0.748,both P＜0.05).ROC analysis showed that the MASP-2 and complement factor H levels had high value in predicting recurrence in autoimmune hepatitis patients,and the area under the curve(AUC)was 0.823 and 0.877,respectively.Conclusion With the exacerbation of the disease,the levels of MASP-2 and complement factor H decrease in patients with autoimmune hepatitis,and these two indicators have high value in predicting the recurrence of autoimmune hepatitis patients,which can be used to assess the severity and prognosis of the disease.
Autoimmune hepatitisMannose associated serine protease 2Complement factor HSeverity of diseaseRecurrence
万方数据
维普
