Breast cancer is a malignant tumor originating from breast epithelial tissue,and its incidence rate is increasing year by year.Studies have shown that the level and regulation of lipid metabolism play an important role in the tumor cell proliferation,migration,invasion,metastasis,and development of drug resistance.This paper reviews the role and mechanism of lipid metabolism in the breast cancer progression from three aspects:lipid metabolism components(fatty acids,triglycerides and cholesterol),lipid metabolism signaling pathway,and regulatory genes of lipid metabolism,offers insights into the potential clinical value of targeted lipid metabolism therapy,and provides theoretical references for formulating effective treatment strategies and developing metabolism-targeted drugs.
关键词
乳腺癌/脂质代谢/信号通路/调控基因/作用机制/进展
Key words
Breast cancer/Lipid metabolism/Signaling pathways/Regulatory genes/Mechanism of action/Progress
维普
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