Efficacy of ceramide cream in adjuvant treatment of patients with facial sensitive skin
Objective To investigate the efficacy and safety of ceramide cream in the adjuvant treatment of patients with facial sensitive skin,and to analyze its effect on skin barrier function.Methods A total of 60 patients with facial sensitive skin who were treated in Department of Dermatology,Guangdong Second Provincial General Hospital from June 2022 to April 2023 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 30 cases in each group.There were 3 males and 27 females in the control group;they were 22-39(27.97±4.80)years old;their disease course was 1 week to 5 months.There were 3 males and 27 females in the observation group;they were 19-42(31.33±6.42)years old;their disease course was 1 week to 5 months.The control group were treated with cetirizine hydrochloride tablets and took anti-sensitivity treatment;in addition,the observation group were treated with ceramide cream.The clinical efficacies,skin cuticle water contents,transepidermal water loss(TEWL),skin oil contents,skin erythema volumes,and incidences of adverse reactions were compared between the two groups by t and x2 tests.Results The total effective rate in the observation group was higher than that in the control group[96.67％(29/30)vs.76.67％(23/30)],with a statistical difference(x2=5.192;P=0.022).Before the treatment and the first week of the treatment,there were no statistical differences in the skin cuticle water content and TEWL between the two groups(all P＞0.05).The second and forth week of the treatment,the skin cuticle water contents in the observation group were higher than those in the control group[(159.4±30.38)ps vs.(144.9±24.50)ps and(172.5±27.70)ps vs.(152.8±20.56)ps];the TEWL's in the observation group were lower than those in the control group[(21.00±3.05)g/m2/h vs.(22.87±2.87)g/m2/h and(18.93±2.98)g/m2/h vs.(21.93±2.73)g/m2/h];there were statistical differences(t=2.035,3.128,2.440,and 4.071;all P＜0.05).Before the treatment and the first and second week of the treatment,there were no statistical differences in the skin oil contents and skin erythema volumes between the two groups(all P＞0.05).The forth week of the treatment,the skin oil content in the observation group was higher than that in the control group[(5.60±2.39)％vs.(4.13±2.16)％];the skin erythema volume in the observation group was lower than that in the control group[(12.43±1.76)mm2 vs.(14.12±1.79)mm2];there were statistical differences(t=2.495 and 3.679;both P＜0.05).No significant adverse reactions occurred in both groups during the treatment.Conclusion Ceramide cream has a good auxiliary repair effect on facial sensitive skin,can help reduce the patients'clinical symptoms,has certain application value in promoting the recovery of skin barrier function,and has few adverse reactions and better safety.
Sensitive skinCeramide creamEfficacySafetySkin barrier function
万方数据
维普
