Electrophysiological subtypes and prognosis of patients with Guillain-Barré syndrome
Objective To study the relation between electrophysiological subtypes and prognosis of patients with Guillain-Barré syndrome(GBS).Methods One hundred and sixty-eight patients with GBS treated at Department of Neurology,Xijing Hospital from September 2020 to October 2023 were selected.According to the Hadden neurophysiological classification criteria,the patients were divided into 5 types.The follow-up score of Hughes was used as the prognosis evaluation indicator.The patients whose Hughes score was 3-6 were set as a poor prognosis group,and the patients whose score was 1-2 a good prognosis group.The observation indicators included gender,age,peak Hughes score,peak mRC score,time from onset to follow-up,cerebrospinal fluid immunoglobulin(IgG),serum anti-GM antibody,prodromal gastrointestinal infections,mechanical ventilation,significant blood pressure fluctuation,and immunoglobulin therapy.Blind follow-up was conducted on the patients through telephone,outpatient daprtment,and hospitalization.x2 test was used.Univariate and multivariate COX regressions and survival curve analysis were used to analyze the risk ratio(RR)that electrophysiological typing affected the patients'prognosis.Results A total of 168 cases were enrolled,including 100 males and 68 females.Twenty-nine cases had poor prognosis including 8 cases who died(6 men and 2 women);139 cases had good prognosis.There were,cases(40.48％)of axonal type,61 cases(36.31％)of demyelinating type,20 cases(11.90％)of unclear type,10 cases(5.95％)of normal type,and 9 cases(5.36％)of neural denervation type.The multivariate COX proportional hazards model suggested the axonal subtype(RR=4.871,95％CI 1.397-16.983,P=0.013),male(RR=3.295,95％CI 1.117-9.718,P=0.031),and 40-65 years old(RR=2.565,95％CI1.011-6.512,P=0.047)were associated with poor outcomes.Conclusion Axonal type is the main risk factor of poor prognosis of patients with GBS.
万方数据
维普
