Intense pulsed light combined with recombinant human type Ⅲ collagen dressing for patients with rosacea
Objective To evaluate the clinical effect of intense pulsed light(IPL)combined with recombinant human type Ⅲ collagen dressing in the treatment of patients with rosacea.Methods One hundred and twenty-two patients with rosacea treated at Department of Dermatology,Yan'an People's Hospital from April 2020 to April 2023 were selected for the randomized controlled trial,and were divided into an IPL group and a treatment group by the random number table method,with 61 cases in each group.There were 31 males and 30 females in the IPL group;they were(31.63±5.57)years old;their disease course was(3.49±1.31)years;they were treated by IPL.There were 34 males and 27 females in the treatment group;they were(30.18±5.14)years old;their disease course was(3.36±1.27)years;they were treated by IPL and recombinant human type Ⅲ collagen dressing.The clinical efficacies,rosacea researchers'general assessment(IGA)scores,VISIA red zone measurements,skin physiological indicators,physicians'global assessment(PGA),Acne-specific quality of life(Acne-QOL),and treatment-related adverse events were compared between the two groups.t and x2 tests were applied.Results Four weeks after the treatment,the total effective rate in the treatment group was higher than that in the IPL group[91.80％(56/61)vs.73.77％(45/61)],with a statistical difference(x2=6.960;P=0.008).Before the treatment,there were no statistical differences in the score of IGA,facial VISIA red zone measurement value,transepidermal water loss(TEWL),skin grease,water in cuticle,skin injury degree,and life quality score between the two groups(all P＞0.05).Four weeks after the treatment,the score of IGA,TEWL,and skin grease in the treatment group were lower than those in the IPL group[(2.27±0.83)vs.(3.83±0.86),(12.29±2.91)％vs.(16.45±2.17)％,and(70.31±11.92)μg/cm2 vs.(83.64±13.83)μg/cm2];the facial VISIA red zone measurement value,water in cuticle,and scores of PGA,self-perception,emotion function,rosacea symptoms,and social function in the treatment group were higher than those in the IPL group[(56.82±12.56)vs.(42.31±10.97),(67.91±11.24)％vs.(56.26±10.39)％,(2.82±0.87)vs.(2.25±0.81),(22.52±2.71)vs.(18.73±2.52),(16.83±2.74)vs.(14.32±2.18),(20.52±2.46)vs.(17.93±2.38),and(19.74±2.85)vs.(15.83±2.14)],with statistical differences(t=10.194,8.951,5.702,6.796,5.944,3.745,7.999,5.599,5.910,and 8.568;all P＜0.05).There was no statistical difference in the incidence of adverse events between the treatment group and the IPL group[6.56％(4/61)vs.11.48％(7/61);x2=0.899;P=0.343].Conclusion IPL combined with recombinant human type Ⅲ collagen dressing for patients with rosacea is effective and safe,and can improve their overall skin conditions and quality of life,so it is worth being clinically generalized.
Intense pulsed lightRosaceaRecombinant human type Ⅲ collagen dressingTreatment efficacySafety
万方数据
维普
