Correlation of TXB2 and S100B in cerebrospinal fluid with prognosis of patients with hypertensive intracerebral hemorrhage
Objective To explore the correlation of thromboxane B2(TXB2)and S100 calcium binding protein B(S100B)in cerebrospinal fluid with the prognosis of patients with hypertensive intracerebral hemorrhage.Methods Ninety-six patients with hypertensive intracerebral hemorrhage admitted to Emergency Department,Chang'an Hospital between May 2020 and May 2023 were selected.All the patients underwent minimally invasive hematoma removal surgery.Their medical records were collected.Their levels of TXB2 and S100B in the cerebrospinal fluid were measured 24 hours after surgery.According to their prognosis 28 d after the surgery,they were divided into a good prognosis group and a poor prognosis group.The factors influencing their prognosis were analyzed.The efficacies of TXB2 and S100B in cerebrospinal fluid in the prediction of the patients'prognosis were evaluated.x2 and independent-sample t tests were used.The multivariate logistic stepwise regression model was used to analyze the influencing factors.Results Twenty-eight days after the surgery,among the 96 patients,68(70.83％)had good prognosis,while the remaining 28(29.17％)had poor prognosis.There were no statistical differences in gender,age,and body mass index between the two groups(all P＞0.05).The score of National Institute of Health Stroke Scale(NIHSS)and proportion of the patients with midline shift in the good prognosis group were lower than those in the poor prognosis group[(15.34±2.61)vs.(20.18±3.32),19.12％(13/68)vs.39.29％(11/28);both P＜0.05].The levels of TXB2 and S100B in cerebrospinal fluid in the good prognosis group were lower than those in the poor prognosis group[(156.04±17.31)ng/L vs.(190.35±18.29)ng/L,(1.72±0.34)μg/L vs.(1.93±0.47)μg/L;both P＜0.05].The score of NIHSS(OR=3.691,95％CI 1.262-10.799),proportion of the patients midline shift(OR=3.425,95％CI 1.171-10.019),and TXB2(OR=5.675,95％CI 1.939-16.602)and S100B(OR=4.486,95％CI 1.533-13.125)in cerebrospinal fluid were the risk factors for the patients'prognosis(all P＜0.05).The sensitivities of TXB2 and S100B in cerebrospinal fluid and their combination in the prediction of the patients,prognosis were 0.764,0.727,and 0.799,respectively;the specificities were 0.641,0.703,and 0.782,respectively;the areas under the curves were 0.731,0.705,and 0.823,respectively.Conclusion The changes in TXB2 and S100B in cerebrospinal fluid are related to the prognosis of patients with hypertensive intracerebral hemorrhage,and both indicators have good predictive efficacies for the patients'prognosis.
Hypertensive cerebral hemorrhageCerebrospinal fluidThromboxane B2S100 calcium binding protein BPrognosis
万方数据
维普
