Sedation effect of remimazolam tosilate in painless gastroenteroscopy
Objective To explore the sedation effect of remimazolam tosilate for injection in painless gastroenteroscopy.Methods Four hundred and eight patients undergoing painless gastroenteroscopy in Yanggu County People's Hospital from December 2022 to January 2024 were selected for the randomized controlled trial,with 204 cases in each group.They were divided into a remimazolam tosilate for injection group(group R)and a propofol group(group P)by the random number table method,with 204 cases in each group.There were 113 males and 91 females in group R;they were(37.68±5.33)years old;their body mass index was(22.41±1.57)kg/m2;there were 127 cases of grade Ⅰ and 77 cases of grade Ⅱ of American Society of Anesthesiologists grading.There were 127 males and 77 females in group P;they were(38.09±5.76)years old;their body mass index was(22.56±1.74)kg/m2;there were 130 cases of grade Ⅰ and 74 cases of grade Ⅱ of ASA grading.The success rates,induction times and recovery times of sedation,incidences of hypotension,treated hypotension,and respiratory depression,and hemodynamic parameters[diastolic blood pressure(DBP),systolic blood pressure(SBP),heart rate(HR),blood oxygen saturation(SpO2),respiratory rate(RR)]at different time points(before the induction and 1,3,6,9,12,15,and 20 min after the induction)were compared between the two groups.The satisfaction and adverse reactions were recorded.The analysis of repeated measurement variance,t test,and x2 test were used.Results The success rates of sedation in the two groups both were 100.00％(204/204).The induction time and recovery time of sedation in group R were shorter than those in group P[(34.19±4.52)s vs.(40.52±5.06)s and(5.72±1.07)min vs.(7.33±1.28)min;t=13.325 and 13.784;both P＜0.05].The incidences of hypotension,treated hypotension,and respiratory depression in group R were lower than those in group P[10.29％(21/204)22.55％vs.(46/204),2.94％(6/204)vs.8.82％(18/204),and 5.39％(11/204)vs.11.27％(23/204);x2=11.161,6.375,and 4.620;all P＜0.05].One,3,6,9,and 12 min after the induction,the SBP,DBP,HR,RR,and SpO2 decreased first and then increased in both groups,and there were statistical differences between the two groups(all P＜0.05).The scores of satisfaction of the patients,anesthesiologists,and endoscopists in group R were higher than those in group P[(8.24±0.76)vs.(6.37±1.16),(8.08±0.82)vs.(6.53±1.37),(8.59±0.60)vs.(7.12±1.24);t=19.259,13.866,and 15.242;all P＜0.05].The incidence of hypoxemia and total incidence of adverse reactions in group R were lower than those in group P[7.35％(15/204)vs.18.14％(37/204)and 20.10％(41/204)vs.31.37％(64/204);x2=10.667 and 6.784;both P＜0.05].Conclusions Sedation effect of remimazolam tosilate for injection is significant in painless gastroenteroscopy.It can maintain hemodynamics stability,shorten recovery time,reduce the incidence of adverse reactions(hypotension and hypoxemia),and improve satisfaction.
SedationRemimazolam tosilate for injectionPainless gastroenteroscopyAdverse reactions
万方数据
维普
