Effect of Mediterranean diet on patients with cachexia induced by colorectal cancer
Objective To explore the effects of Mediterranean diet on the nutritional status,muscle mass and strength,and inflammatory factors in patients with cachexia induced by colorectal cancer.Methods One hundred and sixty-five patients with cachexia induced by colorectal cancer treated at Lianyungang Second People's Hospital from January 2020 to June 2023 were selected for the randomized controlled trial,and were divided into a control group(83 cases)and an observation group(82 cases)by the random number table method.There were 48 males and 35 females in the control group;they were(62.87±5.56)years old.There were 45 males and 37 females in the observation group;they were(63.36±4.84)years old.The control group took conventional nutritional support,and the observation group Mediterranean diet,for 8 weeks.After the intervention,the muscle mass,grip strengths,body weights,upper arm muscle circumferences,skinfold thicknesses,levels of chloride ion(Cl-),sodium(Na),potassium(K),prealbumin(PA),albumin(ALB),total protein(TP),C-reactive proteins(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α),and total response rates were compared between the two groups by t andx2 tests.Results There was no statistical difference in the total response rate between the two groups(x2=1.652,P=0.199).After the intervention,the electrolyte test indicators,nutritional indicators,inflammatory factors,muscle mass,grip strength,body weight,upper arm muscle circumference,and skinfold thickness were better than those before the intervention in both groups(all P＜0.05).After the intervention,the total body fat mass,total body muscle mass,trunk muscle mass,and trunk fat mass in the observation group were(44.36±2.06)kg,(14.46±2.65)kg,(26.85±3.11)kg,and(12.32±3.62)kg,which were higher than those in the control group(t=2.317,2.689,2.787,and 2.337;all P＜0.05);the grip strength,body weight,upper arm muscle circumference,skinfold thickness,and levels of Cl-,Na,K,TP,ALB,PA,CRP,IL-6,and TNF-α in the observation group were(267.84±8.45)N,(65.58±4.65)kg,(24.58±3.32)cm,(14.87±2.33)mm,(102.63±5.51)mmol/L,(139.85±7.52)mmol/L,(0.48±0.13)mmol/L,(68.97±4.62)g/L,(38.89±4.63)g/L,(215.65±13.32)g/L,(18.75±3.31)mg/L,(15.65±2.31)ng/L,and(20.12±2.86)ng/L,which were better than those in the control group(t=4.327,3.309,2.559,3.285,8.404,8.668,2.870,6.547,5.566,4.430,15.173,14.300,and 19.883;all P＜0.05).Conclusion Mediterranean diet for patients with cachexia caused by colorectal cancer is effective,and can maintain their body needs,improve their nutritional status and muscle strength and quality,and reduce the levels of inflammatory factors,so it is worthy of promotion.
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