Expression of T lymphocyte subsets and IL-6 in patients with gastric cancer and their correlation with prognosis
Objective To analyze the expression of peripheral blood T lymphocyte subsets and interleukin-6(IL-6)in patients with gastric cancer,and to explore their correlation with prognosis.Methods A total of 106 patients with gastric cancer treated at Lianyungang Second People's Hospital from June 2021 to June 2023 were selected as an experimental group,and their peripheral blood T lymphocyte subsets(CD3+,CD4+,and CD8+)and IL-6 levels were detected the day after they were admitted to the hospital.Eighty healthy people who came to the hospital for physical examination at the same time were selected as a control group,and their peripheral blood T lymphocyte subsets and IL-6 levels were detected on the day of physical examination.The T lymphocyte subsets and IL-6 levels were compared between the two groups.The patients were followed up 6 months after discharge,and were divided into a poor prognosis group(17 cases)and a good prognosis group(89 cases)according to death and survival.There were 10 males(58.82％)and 7 females(41.18％)in the poor prognosis group;they were(60.47±5.89)years old;9 cases'(52.94％)education level was middle school or above,and 8 cases'(47.06％)below middle school.In the good prognosis group,there were 55 males(61.80％)and 34 females(38.20％);they were(60.08±5.71)years old;32 cases'(35.96％)education level was middle school or above,and 57 cases'(64.04％)below middle school.The logistic regression analysis was done for the prognostic factors in the patients.The receiver operating characteristic curves(ROC)were drawn to evaluate the values of peripheral blood T lymphocyte subsets and IL-6 in the prediction of the patients'prognosis.t and x2 were applied.Results The levels of CD 3+and CD4+in the experimental group were lower than those in the control group[(55.27±8.72)％vs.(68.97±6.45)％and(26.42±10.21)％vs.(38.12±5.07)％];the levels of CD8+and IL-6 in the experimental group were higher than those in the control group[(33.36±6.02)％vs.(24.66±3.75)％and(6.97±3.29)ng/L vs.(3.62±1.01)ng/L];there were statistical differences(t=-11.821,-9.413,11.360,and 8.803;all P＜0.05).The levels of CD3+and CD4+in the poor prognosis group were lower than those in the good prognosis group[(45.12±10.06)％vs.(57.21±6.97)％and(20.01±10.12)％vs.(27.64±9.81)％];the levels of CD8+and IL-6 and the proportion of the patients of tumor stage IV in the poor prognosis group were higher than those in the good prognosis group[(40.12±6.01)％vs.(32.07±5.12)％,(9.75±3.16)ng/L vs.(6.44±3.05)ng/L,and 70.59％(12/17)vs.32.58％(29/89)];there were statistical differences(t=-6.068,-2.924,5.774,and 4.077;x2=8.692;all P＜0.05).The logistic regression analysis showed that tumor stage and CD3+,CD8+,and IL-6 levels were the factors influencing the patients'prognosis(all P＜0.05).The areas under the ROC's of CD3+,CD8+,and IL-6 for predicting the patients'adverse prognosis were 0.847,0.853,and 0.768,respectively.Conclusions In patients with gastric cancer,the levels of CD3+and CD4+are low,and the levels of CD8+and IL-6 are high.The levels of CD3+,CD8+,and IL-6 affect the prognosis of patients with gastric cancer.
Gastric cancerPeripheral blood T lymphocyte subsetsInterleukin-6Prognosis
万方数据
维普
