Preliminary analysis of immune status and main organ function in patients with pulmonary tuberculosis after liver transplantation
Objective To explore the clinical characteristics of immune status and organ function in patients with pulmonary tuberculosis after liver transplantation compared with common pulmonary tuberculosis patients,and to provide scientific basis for regulating the clinical diagnosis and treatment of anti-tuberculosis.Methods The data of inpatients in Guangzhou Chest Hospital from 2014 to 2023 were retrospectively collected.A total of 24 inpatients with pulmonary tuberculosis after liver transplantation were selected as the study group,and 31 inpatients with pulmonary tuberculosis without organ transplantation were selected as the control group.The study group were all male,and the age ranged from 37 to 75 years old,with an average age of 57 years old.The control group were all male,and the age ranged from 32 to 75 years old,with an average age of 57 years old.The data of their first test results of blood routine test,inflammatory markers,liver function,kidney function,heart function,lymphocyte subsets,and other laboratory test results were collected and compared between the two groups.The abnormal proportions of the above indicators and various types of white blood cells and platelet count were compared between the two groups.x2 test and rank sum test were used.Results The abnormal rates of leukocytes,lymphocytes,platelets,hemoglobin,y-glutamyltranspeptidase,creatinine,cystatin C,creatine kinase,B-type natriuretic peptide precursor,and CD3+,CD4+,and CD8+lymphocyte subsets in the study group were higher than those in the control group(all P＜0.05).The lymphocyte-leukocyte ratio[0.13(0.09,0.17)]and lymphocyte-neutrophil ratio[0.17(0.12,0.25)]in the study group were lower than those in the control group[0.18(0.12,0.21)and 0.26(0.15,0.33)],and the monocyte-lymphocyte ratio[0.59(0.49,0.96)]was higher than that in the control group[0.40(0.33,0.63)](all P＜0.05).Conclusion The impaired function of major organs including liver,kidney,and heart and hypoimmunity in patients with pulmonary tuberculosis after liver transplantation are very common,which must be paid close attention to in the process of clinical treatment.
Liver transplantationTuberculosis/pulmonaryOrgan functionImmune function
万方数据
维普
