Relationships between LMR,MPVLR and radiation pneumonia after radical radiotherapy in patients with stage Ⅲ lung cancer
Objective To explore the relationships between lymphocyte to monocyte ratio(LMR),mean platelet volume to lymphocyte ratio(MPVLR)and radiation pneumonia after radical radiotherapy in patients with stage Ⅲ lung cancer.Methods A total of 102 patients with stage Ⅲ lung cancer who received radical radiotherapy in the Department of Radiotherapy,Shaanxi Provincial Cancer Hospital from February 2020 to March 2023 were selected as the study objects.There were 85 males and 17 females,aged 32-76(51.17±8.27)years,with a body mass index(BMI)of 22.46-24.52(23.06±1.57)kg/m2.The monocyte count,mean platelet volume,and lymphocyte count before radiotherapy were measured by automatic blood analyzer,and the LMR and MPVLR values were calculated according to the test results.The patients were followed up for 3 months and were divided into an occurrence group(23 cases)and a non-occurrence group(79 cases)according to whether they developed radiation pneumonia.The receiver operating characteristic curve(ROC)was used to evaluate the predictive values of peripheral blood LMR and MPVLR for radiation pneumonia after radical radiotherapy in patients with stage Ⅲ lung cancer.Multivariate logistic regression analysis was used to explore the influencing factors of radiation pneumonia after radical radiotherapy in patients with stage Ⅲ lung cancer.Independent sample t test and x2 test were used.Results The LMR and MPVLR before radiotherapy in the occurrence group were lower than those in the non-occurrence group(both P＜0.05).The areas under the curves(AUCs)(95％CI)of peripheral blood LMR and MPVLR before radiotherapy for predicting radiation pneumonia after radical radiotherapy in patients with stage Ⅲ lung cancer were 0.745(0.695-0.791)and 0.862(0.812-0.907),respectively,and the AUC(95％CI)of the combined detection was 0.916(0.871-0.966).The proportions of the patients with central gross type,tumor diameter ≥5 cm,and total dose ≥60 Gy in the occurrence group were higher than those in the non-occurrence group(all P＜0.05).Multivariate logistic regression analysis showed that total radiation dose(OR=2.217,95％CI:1.452-3.385),tumor diameter(OR=2.368,95％CI:1.409-3.980),decreased LMR(OR=2.649,95％CI:1.658-4.231),and elevated MPVLR(OR=3.177,95％CI:1.868-5.404)were risk factors for radiation pneumonia after radical radiotherapy in patients with stage Ⅲ lung cancer(all P＜0.05).Conclusions Low expression of LMR and high expression of MPVLR in the peripheral blood of lung cancer patients with radiation pneumonia after radical radiotherapy are observed,and LMR and MPVLR have a certain relationship with the occurrence of radiation pneumonia after radical radiotherapy.Both of them are influencing factors for the occurrence of radiation pneumonia after radical radiotherapy for lung cancer,and their combined detection has a higher value in the evaluation of radiation pneumonia after radical radiotherapy for lung cancer.
Lymphocyte to monocyte ratioMean platelet volume to lymphocyte ratioLung cancerRadiotherapyRadiation pneumonia
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