Relationships between T lymphocyte subsets and serum CD64,TLR2 and recurrence after discharge in AECOPD patients
Objective To explore the relationships between T lymphocyte subsets and serum CD64,Toll like receptor 2(TLR2)and recurrence after discharge in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A retrospective analysis was conducted on 120 cases of AECOPD admitted to Xi'an Central Hospital from January 2020 to October 2023.Among them,there were 70 males and 50 females,aged 51-84(69.01±11.09)years,and the course of COPD was 6-12(8.95±2.29)years.All patients were divided into a recurrence group(40 cases)and a non-recurrence group(80 cases)based on whether they had relapsed(acute deterioration worsened)within 90 days of telephone or outpatient follow-up after discharge.The general information[gender,age,COPD course,underlying diseases,smoking history,drinking history,and COPD Patient Self-Assessment Test(CAT)score],T lymphocyte subsets(CD3+,CD4+,CD8+,and CD4+/CD8+),CD64,and TLR2 levels were compared between the two groups.The influencing factors of recurrence in AECOPD patients after discharge were identified by multi-factor unconditional logistic stepwise regression analysis.Finally,the values of forced expiratory volume in 1 second/forced vital capacity(FEV1/FVC),T lymphocyte subsets,CD64,and TLR2 levels in predicting recurrence in AECOPD patients after discharge were analyzed by the receiver operating characteristic curve(ROC).Independent sample t test and x2 test were used.Results The levels of FEV1/FVC,CD3+,CD4+,and CD4+/CD8+in the recurrence group were lower than those in the non-recurrence group,and the levels of CD8+,CD64,and TLR2 were higher than those in the non-recurrence group,with statistically significant differences(all P＜0.05).Multivariate logistic regression analysis showed that the levels of FEV1/FVC,T lymphocyte subsets,CD64,and TLR2 were the influencing factors for recurrence in AECOPD patients after discharge(all P＜0.05).ROC analysis confirmed that FEV1/FVC,CD3+,CD4+,CD8+,CD4+/CD8+,CD64,and TLR2 levels could be used to predict recurrence in AECOPD patients after discharge,with the areas under the curves of 0.810,0.639,0.912,0.793,0.945,0.632,and 0.908(all P＜0.05).Conclusion The recurrence of AECOPD patients after discharge is influenced by FEV1/FVC,T lymphocyte subsets,CD64,and TLR2 levels,which should be closely monitored clinically.
Acute exacerbation of chronic obstructive pulmonary diseaseT lymphocyte subsetsCD64Toll like receptor 2Recurrence after discharge
万方数据
维普
