目的 就运动对化疗致周围神经病变干预效果的系统评价进行再评价，以期为癌症化疗致周围神经病变患者制定运动干预方案提供依据。方法 通过主题词结合自由词的方式，用计算机系统检索 9个数据库:PubMed、Web of Science、EMBASE、The Cochrane Library、CINAHL、中国知网(CNKI)、万方数据库(Wangfang)、维普数据库(VIP)以及中国生物医学文献数据库(CBM)，检索运动对化疗致周围神经病变影响的系统评价/meta分析，检索时限为建库至2023年8月20日，由两名研究者独立对检索获得的文献进行筛选和数据提取。结果 经过筛选后共纳入9篇系统评价/meta分析，系统评价方法学质量评价结果为3篇文献低质量、6篇文献极低质量。对23条证据进行推荐分级的评估、制定与评价(GRADE)分级，得到高级证据1条、中级证据5条、低级证据9条、极低级证据8条。结论 运动对化疗致周围神经病变效果的系统评价/meta分析文献质量总体不高，证据数量较少且总体证据强度较低，未来仍需严谨规范地开展多中心、大样本研究，以提供更高质量的证据。
Overviews of the effect of exercise on chemotherapy-induced peripheral neuropathy
Objective To evaluate the systematic reviews of the effect of exercise on chemotherapy-induced peripheral neuropathy,with a view to provide a basis for the development of exercise intervention programs for patients with peripheral neuropathy due to cancer chemotherapy.Methods Systematic reviews/meta-analysis of the effect of exercise on chemotherapy-induced peripheral neuropathy were searched in nine databases by combining subject terms with free words:CNKI,Wangfang,VIP,CBM,PubMed,Web of Science,EMBASE,The Cochrane Library,and CINAHL.The search time limit was from the inception of the database until August 20,2023,and the literatures obtained were independently screened and extracted by two researchers.Results A total of 9 systematic reviews/meta-analyses were included,and the methodological quality assessment of the systematic reviews showed that 3 were of low quality and 6 were of very low quality.The grades of recommendations assessment,development and evaluation(GRADE)grading of the 23 pieces of evidence showed 1 piece of high-level evidence,5 pieces of intermediate evidence,9 pieces of low-level evidence,and 8 pieces of extremely-low-level evidence.Conclusion The systematic reviews/meta-analysis of the literatures on the effect of exercise on chemotherapy-induced peripheral neuropathy are of generally low quality,with low volume and overall strength of evidences,and multicenter,large-sample,high-quality studies are still needed to further assess its effect in the future.
CancerChemotherapyPeripheral neuropathyExerciseEvidence-based nursingOverview of systematic review
万方数据
维普
