Relationships between Th1,Th 17,and miR-150 expressions and disease progression in patients with psoriasis vulgaris
Objective To investigate the relationships between the expression levels of peripheral blood T helper cell(Th)1,Th17,and miR-150 and the progression of psoriasis vulgaris(PV).Methods A total of 112 PV patients admitted to Baoji People's Hospital from February 2021 to April 2023 were selected as a PV group,and 60 healthy individuals during the same period were selected as a control group.There were 63 males and 49 females in the PV group,aged(46.89±12.35)years.In the normal group,there were 32 males and 28 females,aged(44.36±11.22)years.According to the Psoriasis Area and Severity Index(PASI),the PV group was divided into mild,moderate,and severe groups.The levels of Th1,Th17,and miR-150 in the PV group and the control group were compared,and the levels of Th1,Th17,miR-150,and related cytokines[interleukin(IL)-2,IL-17,and IL-22]in the mild,moderate,and severe groups were compared.The correlations between the expression levels of Th1,Th17,and miR-150 and PASI score were analyzed.The statistical methods used were t test,F test,x2 test,and Pearson correlation analysis.Results The levels of Th1 and Th17 in the PV group were higher than those in the control group[(22.76±3.21)％vs.(16.83±1.65)％,(3.35±0.68)％vs.(1.25±0.37)％],and the level of miR-150 was lower than that in the control group[(0.80±0.09)vs.(0.99±0.15)],with statistically significant differences(t=13.38,22.21,and 10.38,all P＜0.05).The levels of Th1 and Th17 in the mild group were lower than those in the moderate and severe groups,and the level of miR-150 was higher than those in the moderate and severe groups,with statistically significant differences(F=85.29,19.41,and 92.93,all P＜0.05).The levels of 1L-2,IL-17,and IL-22 in the mild group were lower than those in the moderate and severe groups,with statistically significant differences(F=66.03,42.79,and 23.34,all P＜0.05).Pearson correlation analysis showed that the levels of Th1 and Th17 in the peripheral blood of PV patients were positively correlated with PASI score(r=0.771 and 0.514,both P＜0.05),and the level of miR-150 was negatively correlated with PASI score(r=-0.703,P＜0.05).Conclusion Increased levels of Th1 and Th17 and decreased miR-150 level in the peripheral blood of PV patients are associated with the severity of PV progression.
万方数据
维普
