Effect of photodynamic therapy combined with tacrolimus ointment in the treatment of facial rosacea
Objective To investigate the clinical effect of photodynamic therapy combined with tacrolimus ointment in the treatment of facial rosacea and its influence on the levels of serum inflammatory factors.Methods A total of 78 patients with facial rosacea admitted to the Department of Dermatology and Plastic Surgery,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from May 2020 to January 2023 were prospectively selected as research objects,and were divided into a control group and an observation group with 39 cases in each group by the random number table method.In the control group,there were 24 males and 15 females,the age was(34.51±3.17)years old,and the course of disease was(2.13±0.39)years.In the observation group,there were 27 males and 12 females,the age was(33.38±3.25)years old,and the course of disease was(2.19±0.37)years.The control group received photodynamic therapy.The observation group received photodynamic therapy combined with tacrolimus ointment(2 times/day,respectively in the morning and evening,for 1 month).Both groups were treated for 1 month.The clinical efficacy(improvement time of skin flushing,telangiectasia,and erythema),levels of serum inflammatory factors[interleukin 1α(IL-1α),IL-8,and tumor necrosis factor α(TNF-α)],skin lesion scores,and Echelle d'Evaluation Clinique des Cicatrices d'acné(ECCA)scores before and after treatment,and adverse reactions were compared between the two groups.Statistical methods used were t test and x2 test.Results The improvement time of skin flushing,telangiectasia,and erythema in the observation group were shorter than those in the control group[(10.82±1.05)d vs.(14.39±1.70)d,(12.68±1.66)d vs.(15.11±1.00)d,(16.77±1.53)d vs.(19.84±2.81)d],with statistically significant differences(t=11.16,7.83,and 5.99,all P＜0.05).After treatment,the levels of IL-1α,IL-8,and TNF-α,skin lesion score,and ECCA score in the observation group were lower than those in the control group[(4.74±1.11)ng/L vs.(6.43±1.26)ng/L,(23.94±3.11)ng/L vs.(31.30±4.31)ng/L,(27.95±3.45)ng/L vs.(53.13±6.88)ng/L,(3.44±1.04)points vs.(7.50±1.64)points,(26.46±3.08)points vs.(39.92±4.27)points],with statistically significant differences(t=6.29,8.65,20.43,13.06,and 15.97,all P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group[7.69％(3/39)vs.25.64％(10/39)],with a statistically significant difference(x2=4.52,P＜0.05).Conclusion The combined treatment of facial rosacea with photodynamic therapy and tacrolimus ointment effectively improves the skin flushing,telangiectasia,erythema,serum inflammatory factor levels,skin lesions and scar evaluation,and reduces the occurrence of adverse reactions,so as to enhance the clinical efficacy.
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