Comparison of the preventive effects of fondaparinux sodium and nadroparin calcium on postoperative thrombosis in patients with fractures
Objective To compare the effects of fondaparinux sodium injection and nadroparin calcium injection in preventing thrombotic disease in fracture patients after surgery.Methods This study was a randomized controlled trial.A total of 130 patients who underwent fracture surgery in Northwest University First Hospital from January 2022 to January 2024 were selected and were divided into two groups with 65 patients in each group by the random number table method.In the fondaparinux sodium group,there were 38 males and 27 females,the age was(52.37±12.71)years old,and the body mass index(BMI)was(26.5±3.2)kg/m2.In the nadroparin calcium group,there were 39 males and 26 females,the age was(53.19±13.20)years old,and the BMI was(26.7±3.1)kg/m2.In the fondaparinux sodium group,subcutaneous injection of fondaparinux sodium was immediately started after surgery at a dose of 2.5 mg,once a day,lasting for 14 days.In the nadroparin calcium group,subcutaneous injection of nadroparin calcium was given every 12 hours at a dose of 4 100 AXaIU each time for 14 days.The deep vein thrombosis(DVT),pulmonary embolism(PE),swelling and pain of lower limbs,coagulation function indicators,and incidence of adverse reactions were compared between the two groups.Statistical methods used were t test and x2 test.Results There were no statistically significant differences in the incidences of DVT and PE between the fondaparinux sodium group and the nadroparin calcium group[13.84％(9/65)vs.10.76％(7/65),3.07％(2/65)vs.1.53％(1/65)](x2=0.29 and 0.34,both P＞0.05).There was no statistically significant difference between the two groups in terms of postoperative swelling and pain in lower limbs(both P＞0.05).The prothrombin time(PT)was(9.49±1.21)s in the fondaparinux sodium group and(9.47±1.08)s in the nadroparin calcium group before surgery,and(14.61±1.09)s and(14.27±1.12)s on the 14th day after surgery;the thrombin time(TT)was(9.05±1.20)s in the fondaparinux sodium group and(9.07±1.23)s in the nadroparin calcium group before surgery,and(13.24±1.33)s and(15.22±1.29)s on the 14th day after surgery;the PT and TT after surgery were higher than those before surgery in both groups(all P＜0.05).The hypersensitive C-reactive protein(hs-CRP)in the nadroparin calcium group was lower than that in the fondaparinux sodium group on the 14th day after surgery[(13.82±1.77)mg/L vs.(17.71±1.53)mg/L],with a statistically significant difference(t=13.40,P＜0.05).The incidence of adverse reactions was 7.69％(5/65)in the fondaparinux sodium group and 10.76％(7/65)in the nadroparin calcium group,with no statistically significant difference(x2=0.37,P＞0.05).Conclusion Fondaparinux sodium injection and nadroparin calcium injection have similar effects and safety in preventing postoperative thrombotic disease in fracture patients after surgery,which can provide a certain reference for clinical practice.
万方数据
维普
