Clinical efficacy of Chai-Zhi Ping-Gan decoction combined with Xiao-Pi Kuan-Wei decoction in the treatment of liver-stomach disharmony type chronic gastritis
Objective To evaluate the clinical efficacy of Chai-Zhi Ping-Gan decoction combined with Xiao-Pi Kuan-Wei decoction in the treatment of liver-stomach disharmony type chronic gastritis.Methods A total of 94 patients with liver-stomach disharmony type chronic gastritis admitted to No.215 Hospital of Shaanxi Nuclear Industry from January 2020 to April 2023 were included and were divided into a study group and a control group by stratified random sampling method,with 47 cases in each group.In the control group,there were 24 males and 23 females,aged(44.81±5.62)years,with a duration of disease of(2.60±1.35)years.In the study group,there were 23 males and 24 females,aged(45.20±5.47)years,with a duration of disease of(2.56±1.24)years.The control group received standard quad therapy,esomeprazole magnesium enteric-coated tablets,amoxicillin tablets,furazolidone tablets,and bismuth potassium citrate capsules for 2 weeks,after stopping the use of amoxicillin tablets,furazolidone tablets,and bismuth potassium citrate capsules,and continued to take esomeprazole magnesium enteric-coated tablets for 2 weeks.The study group received Chai-Zhi Ping-Gan decoction combined with Xiao-Pi Kuan-Wei decoction treatment.The treatment course of both groups was 4 weeks.The clinical efficacy,traditional Chinese medicine(TCM)symptom score,gastrointestinal function indexes[somatostatin(SST),gastrin(GAS),motilin(MTL),and vasoactive intestinal peptide(VIP)],inflammatory markers[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),and tumor necrosis factor α(TNF-α)],disappearance time of abdominal pain,acid reflux,and belching,and eradication rate of Helicobacter pylori(Hp)of the two groups were compared.Statistical methods used were t test and x2 test.Results The total effective rate of clinical treatment in the study group was higher than that in the control group[97.87％(46/47)vs.85.11％(40/47)],with a statistically significant difference(x2=4.919,P=0.027).After 4 weeks of treatment,the total TCM symptom score in the study group was(3.70±0.53),and that in the control group was(5.52±0.79),with a statistically significant difference(t=13.116,P＜0.001);the levels of SST,GAS,MTL,and VIP in the study group were(299.60±20.18)ng/L,(81.38±6.15)ng/L,(51.60±6.28)ng/L,and(22.35±2.79)ng/L,and those in the control group were(200.19±17.96)ng/L,(70.18±5.62)ng/L,(43.57±5.65)ng/L,and(26.16±4.15)ng/L,with statistically significant differences(t=25.228,9.216,6.517,and 5.223,all P＜0.001);the levels of IL-6,hs-CRP,and TNF-α in the study group were(22.52±7.16)μg/L,(10.65±1.46)mg/L,and(1.50±0.28)μg/L,which were lower than those in the control group[(35.51±7.74)μg/L,(15.88±2.18)mg/L,and(1.94±0.34)μg/L],with statistically significant differences(t=8.446,13.666,and 6.849,all P＜0.001).The disappearance time of abdominal pain,acid reflux,and belching in the study group were(3.57±2.02)d,(3.01±1.11)d,and(3.47±1.33)d,and those in the control group were(7.72±3.57)d,(8.07±3.64)d,and(7.02±4.02)d,with statistically significant differences(t=6.936,9.116,and 5.748,all P＜0.001).Within 30 d after withdrawal,the eradication rate of Hp in the study group was higher than that in the control group[95.74％(45/47)vs.82.95％(39/47)],with a statistically significant difference(x2=4.029,P=0.045).Conclusion Chai-Zhi Ping-Gan decoction combined with Xiao-Pi Kuan-Wei decoction shows significant clinical efficacy in the treatment of liver-stomach disharmony type chronic gastritis,effectively improves the patients'symptoms and physiological indicators,and increases the Hp eradication rate,proving to be a safe and effective treatment choice.
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