Effect of Shenqi Jiangtang granules combined with mecobalamin on blood glucose and pregnancy outcomes in patients with gestational diabetes
Objective To investigate the effect of Shenqi Jiangtang granules combined with mecobalamin on blood glucose control and pregnancy outcomes in patients with gestational diabetes.Methods From June 2020 to June 2023,150 patients with gestational diabetes who were treated in Xianyang Hospital,Yan'an University were selected,and were divided into a traditional Chinese medicine group,a western medicine group,and a combined treatment group,with 50 cases in each group.The traditional Chinese medicine group were(29.33±3.65)years old and(29.75±3.22)weeks pregnant,and took conventional treatment and Shenqi Jiangtang granules 1 g/time,3 times/d.The western medicine group were(29.16±3.06)years old and(30.51±3.41)weeks pregnant,and took conventional treatment and mecobalamin 0.5 mg/time,3 times/d.The combined treatment group were(30.21±3.16)years old and(30.81±3.36)weeks pregnant,and took conventional treatment,Shenqi Jiangtang granules1 g/time,3 times/d,and mecobalamin 0.5 mg/time,3 times/d.All the 3 groups were treated 1 month.The clinical treatment effects,blood glucose qualified rates,blood glucose and lipid indicators,and pregnancy outcomes of the three groups were compared.F,t,and x2 tests were applied.Results The therapeutic efficacy of the traditional Chinese medicine group was 70.00％(35/50),that of the western medicine group 74.00％(37/50),and that of the combined treatment group 94.00％(47/50),with a statistical difference between the 3 groups(x2=7.523,P＜0.05).After 1 month's treatment,the levels of glycosylated hemoglobin(HbA1c),2 hours postprandial plasma glucose(2hBG),fasting blood glucose(FBG),cystatin C(Cys-C),and homocysteine(Hcy)in the combined treatment group were lower than those in the traditional Chinese medicine group and the western medicine group[(5.02±0.63)％vs.(6.33±0.79)％vs.(6.21±0.96)％,(4.02±0.53)mmol/L vs.(5.96±0.75)mmol/L vs.(5.83±0.82)mmol/L,(5.69±0.62)mmol/L vs.(7.36±0.95)mmol/L vs.(6.91±0.77)mmol/L,(8.33±0.95)μmol/L vs.(11.02±1.20)μmol/L vs.(10.86±1.25)μmol/L,and(1.01±0.11)mg/L vs.(1.31±0.16)mg/L vs.(1.28±0.15)mg/L],with statistical differences between the 3 groups(all P＜0.05).The incidence of adverse pregnancy outcomes in the combined treatment group was lower than that in the Chinese medicine group and the western medicine group[8.00％(4/50)vs.30.00％(15/50)vs.29.00％(14/50)],with a statistical difference between the 3 groups(P＜0.05).The blood glucose qualified rate and spontaneous delivery rate of the combined treatment group were obviously higher than those of the traditional Chinese medicine group and the western medicine group[94.00％(47/50)vs.70.00％(35/50)vs.74.00％(37/50)and 70.00％(35/50)vs.40.00％(20/50)vs.44.00％(22/50)],with statistical differences between the 3 groups(both P＜0.05);Conclusion Shenqi Jiangtang granules combined with mecobalamin for patients with gestational diabetes can reduce their blood glucose levels,and can improve their adverse pregnancy outcomes.
万方数据
维普
