Curative effects of two dressings combined with autologous cell spray technique for patients with deep second-degree burn on their hands
Objective To explore the efficacies of two different dressings combined with autologous cell spray technique in the treatment of patients with deep second-degree burns on their hands.Methods Sixty-eight patients with deep second-degree burns on their hands who were treated at Department of Burn,Plastic,and Hand Surgery,Hospital Affiliated to Yan'an University from June 2020 to December 2023 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 34 cases in each group.There were 22 males and 12 females in the control group;they were(35.18±11.34)years old;their burn area was(17.41±3.52)cm2.There were 20 males and 14 females in the observation group;they were(36.84±10.75)years old;their burn area was(18.28±3.39)cm2.The control group were treated with moist exposed burn ointment(MEBO)and autologous cell spray technique,and the observation group with hydrogel dressing and autologous cell spray technique.Both groups were treated for 14 days.The serum levels of inflammatory factors,immune function,and serum levels of pain-inducing factors after 14 days'treatment,scores of hand function and scar 3 months after the treatment,and total efficacies were compared between the two groups using t test and x2 test.Results After the treatment,the wound healing time in the observation group was shorter than that in the control group[(12.48±2.95)d vs.(14.31±3.26)d],with a statistical difference(t=2.43;P＜0.05).After 14 days'treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-8,high-sensitivity C-reactive protein(hs-CRP),and CD8+in the observation group were lower than those in the control group;the levels of CD3+,CD4+,and CD4+/CD8+in the observation group were higher than those in the control group;there were statistical differences(all P＜0.05).The serum levels of pain-inducing factors,prostaglandin E2(PGE2),neuropeptide Y(NPY),and 5-hydroxytryptamine(5-HT),in the observation group were lower than those in the control group[(155.88±28.10)ng/L vs.(172.30±29.97)ng/L,(140.61±19.89)μg/L vs.(154.58±25.79)μg/L,and(118.92±16.75)ng/L vs.(129.57±16.61)ng/L],with statistical differences(t=2.33,2.50,and 2.63;all P＜0.05).Three months after the treatment,the scores of tactile,pain,and motor function of the hands in the observation group were higher than those in the control group[(79.25±8.01)vs.(74.79±7.15),(84.71±9.06)vs.(80.58±7.68),and(68.40±7.88)vs.(63.73±7.17)],with statistical differences(t=2.42,2.03,and 2.56;all P＜0.05).The scores of vascular distribution,color,thickness,and softness of the scars in the observation group were lower than those in the control group,with statistical differences(all P＜0.05).The overall efficacy in the observation group was higher than that in the control group(x2=5.40;P＜0.05).Conclusion Hydrogel dressing combined with autologous cell spray technique for patients with deep second-degree burn on their hands can accelerate wound healing,reduce inflammation,alleviate pain,promote hand function recovery,and improve scar quality and overall efficacy.
Moist burn ointmentHydrogel dressingAutologous cell spray techniqueDeep second-degree burns on the hand
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维普
