Correlation of VEGF and PD-L1 expressions with clinical pathological characteristics in patients with cervical cancer and HPV infection
Objective To investigate the relationship or the expressions or vascular endothelial growth factor(VEGF)and programmed cell death 1 ligand 1(PD-L1)with clinical pathological characteristics in patients with cervical cancer and HPV infection.Methods Eighty patients with advanced cervical cancer treated at Yan'an Traditional Chinese Medicine Hospital from March 2016 to March 2021 were prospectively included in the study.They were(58.41±7.81)years old.There were 18 cases of high differentiation,30 cases of moderate differentiation,and 32 cases of low differentiation.The immunohistochemical methods were used to detect the expressions of VEGF and PD-L1 in the collected tumor tissue slices.The correlation between VEGF and PD-L1 was analyzed.The Kaplan-Meier and Log-Rank methods were used to analyze the overall survival and differences between different subgroups.The Cox regression method was used to analyze the prognostic risk factors.Results Among the 80 patients,39 cases(48.75％)died from the progression of malignant tumors,and 41 cases(51.25％)still survived.The immunohistochemical results showed that the positive expression rates of VEGF and PD-L1 in the patients were 61.25％(49/80)and 52.50％(42/80),respectively.The Spearman correlation analysis showed a positive correlation between VEGF and PD-L1(r=0.682,P=0.015).The expressions of VEGF and PD-L1 related to their degree of differentiation,distant metastasis,and FIGO stage(all P＜0.05);the higher the FIGO stage and lower the degree of differentiation,the higher the relative expression levels of VEGF and PD-L1.The median OS of the patients with positive and negative VEGF expressions were 13.08 months and 14.73 months,respectively;the median OS of the patients with positive and negative PD-L1 expressions were 13.56 months and 15.12 months,respectively.The prognosis of the patients with negative VEGF expression was better than that of the patients with positive VEGF expression,and the prognosis of the patients with negative PD-L1 expression was better than that of the patients with positive PD-L1 expression(Log x2=9.962 and 6.018;P＜0.05).The Cox multivariate regression analysis suggested that VEGF expression,PD-L1 expression,distant metastasis,and FIGO staging were the risk factors affecting the patients'independent prognosis(HR=2.443,2.251,2.194,and 2.587;all P＜0.05).Conclusion VEGF and PD-L1 can serve as important indicators for evaluating the prognosis of patients with cervical cancer and HPV infection,and have certain clinical value.
万方数据
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