Value of hemorheological parameters in prediction of pregnancy outcomes in patients with gestational diabetes mellitus
Objective To analyze and explore the value of hemorheological changes in the prediction of pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods A retrospective analysis was conducted on 80 patients with GDM(a GDM group)who underwent obstetric examination and delivery at Huangshi Maternal and Child Health Hospital from January to December 2020.The patients were divided into a good pregnancy outcome group(35 cases)and a poor pregnancy outcome group(45 cases)according to the pregnancy outcomes.Sixty-eight healthy pregnant women who underwent prenatal examination during the same period were selected as a control group.The GDM group was(30.55±4.23)years old;their body weight was(67.52±6.34)kg;30 cases'education level was high school or below,25 cases'college,and 25 cases'bachelor's degree or above.The control group was(29.84±3.91)years old;their body weight was(66.08±6.01)kg;28 cases'education level was high school or below,20 cases'college,and 20 cases'bachelor's degree or above.The hemorheological parameters were compared between the two groups by x2 and t tests.The multivariate logistic regression model was used to analyze the risk factors affecting poor pregnancy outcomes in the patients.The diagnostic efficacies of hemorheological parameters in predicting poor pregnancy outcomes in the patients were assessed using the receiver operating characteristic curve(ROC).Results The plasma viscosity(PV),hematocrit(HCT),high shear whole blood viscosity(HWBV),low shear whole blood viscosity(LWBV),and erythrocyte sedimentation rate(ESR)of the GDM group were higher than those of the control group[(1.78±0.32)mPs·s vs.(1.54±0.33)mPs·s,(45.60±6.56)％vs.(37.64±5.71)％,(9.41±0.89)mPs·s vs.(7.61±1.44)mPs·s,(7.93±1.34)mPs·s vs.(5.36±1.73)mPs·s,and(62.05±8.73)mm/h vs.(49.55±6.81)mm/h],with statistical differences(all P＜0.05).The PV,HCT,HWBV and LWBV of the good pregnancy outcome group were lower than those of the poor pregnancy outcome group[(1.56±0.33)mPs·s vs.(1.95±0.17)mPs·s,(39.77±2.11)％vs.(50.14±5.12)％,(8.66±0.88)mPs·s vs.(10.00±0.16)mPs·s,and(6.75±0.74)mPs·s vs.(8.85±0.95)mPs·s],with statistical differences(all P＜0.05);there were no statistical differences in the ESR between the two groups(P＞0.05).PV,HCT,HWBV,and LWBV were correlated with the occurrence of adverse pregnancy outcomes in the patients and were the potential risk factors for adverse pregnancy outcomes(OR=17.618,1.160,5.697,and 1.890;all P＜0.05).The sensitivity,specificity,and area under the curve of the combination of the four indicators for assessing adverse pregnancy outcomes in the patients were 95.6％,97.1％,and 0.980.Conclusion Hemorheological indicators have significant value in predicting the pregnancy outcomes of GDM patients,and combined detection can significantly improve the sensitivity and specificity of the diagnosis.
万方数据
维普
