Clinical features and drug resistance of Escherichia coli bloodstream infection at some hospital
Objective To analyze the clinical features and drug resistance of 221 patients with Escherichia coli bloodstream infection at Guangdong Provincial Second Hospital of Traditional Chinese Medicine,and to provide references for the rational use of antimicrobial drugs and the prevention and control of hospital infection in clinical practice.Methods The data of positive blood culture strains at Guangdong Provincial Second Hospital of Traditional Chinese Medicine from January 2021 to December 2023 were collected.The clinical information and drug sensitivity results of 221 patients with non-duplicative Escherichia coli bloodstream infection were screened,including 95 males(42.99％)and 126 females(57.01％);they were 26-97 years old.According to the production of extended spectyum beta-lactamase(ESBLs),they were divided into an ESBLs group(105 cases)and a non-ESBLs group(116 cases).The resistance rates were compared between the two groups by x2 test.Results From January 2021 to December 2023,there were 552 cases of positive blood culture in the hospital,including 221 patients with Escherichia coli bloodstream infection.The patients were mainly from the departments of acupuncture(55 cases)and oncology(31 cases).There were 105 ESBLs-producing Escherichia coli strains,accounting for 47.51％of the total strains.Escherichia coli had high resistance rates to levofloxacin(54.30％),cotrimoxazole(50.68％),ceftriaxone(53.39％),and cefuroxime(53.85％),but had high sensitivity to amikacin(3.62％),carbapenems(5.43％),and ertapenem(5.43％).ESBLs-producing Escherichia coli had higher resistance rates to imipenem,ertapenem,ceftazidime,cefepime,ceftriaxone,cefuroxime,and levofloxacin than non-ESBL-producing Escherichia coli(all P＜0.05).Conclusions Escherichia coli bloodstream infection is mainly distributed in the departments of acupuncture and oncology.Most strains produce ESBLs and are resistant to many common antibiotics,but they are highly sensitive to carbapenems,so antimicrobial drugs should be reasonably selected in clinical practice to reduce the generation of drug-resistant bacteria.
万方数据
维普
