Analysis of prevalence and risk factors of emotional abnormalities in patients with anal cryptitis
Objective To analyze the prevalence and risk factors of emotional disorders in patients with anal cryptitis(AC).Methods Three hundred and twenty outpatients and inpatients with AC treated at Xi'an Hospital of Traditional Chinese Medicine from January 2021 to January 2024 were selected as the study objects.All the patients were evaluated by Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS).According to the occurrence of emotional abnormalities,the patients with emotional abnormalities were set as an emotional abnormality group,including 55 males and 71 females whose body mass index was(25.10±1.39)kg/m2,and the patients without emotional abnormalities a non-emotional abnormality group,including 89 males and 105 females whose body mass index was(24.88±1.41)kg/m2.All the patients'baseline data were statistically analyzed.The relationship of anxiety and depression with intestinal flora was analyzed by bivariate correlation Pearson.Binary logistic regression was used to analyze the risk factors of emotional abnormalities in the patients with AC,and a nomogram was constructed.t,non-parameter Mann-Whitney U,and x2 tests were used.Results The scores of SAS and SDS in the emotional abnormality group were higher than those in the non-emotional abnormality group[(68.66±5.82)vs.(52.87±3.59)and(69.18±5.03)vs.(53.62±3.65)],with statistical differences(t=30.02 and 32.03;both P＜0.05).The levels of Lactobacillus,Enterococcus,and Bifidobacterium in the emotional abnormality group were lower than those in the non-emotional abnormality group[(6.67±1.02)logN/g vs.(8.28±1.26)logN/g,(6.75±1.32)logN/g vs.(7.88±1.09)logN/g,and(7.11±1.13)logN/g vs.(8.02±1.04)logN/g],with statistical differences(t=12.01,8.33,and 7.39;all P＜0.05).The scores of SAS and SDS were negatively correlated with the levels of Lactobacillus,Enterococcus,and Bifidobacterium(all r＜0;all P＜0.05).The disease course in the emotional abnormality group was longer than that in the non-emotional abnormality group(P＜0.05);the scores of Numeric Pain Rating Scale(NRS)and Insomnia Severity Index(ISI)and the proportions of the patients with concomitant diseases and the patients who did not took the primary treatment in the emotional abnormality group were higher than those in the non-emotional abnormality group(all P＜0.05).The scores of NRS and ISI and concomitant diseases were the risk factors of emotional abnormalities in the patients with AC(all OR＞1;all P＜0.05);the levels of Lactobacillus,Enterococcus,and Bifidobacterium were the protective factors of of emotional abnormalities in the patients with AC(all OR＜1;all P＜0.05).Bootstrap was used to verify the nomogram model;the internal verification was carried out through the modeling group;the results showed that the C-index value was 0.944,and the calibration curve was in good agreement with the ideal curve;the area under the curve(AUC)was 0.917(95％CI 0.869-0.965,P＜0.001).Conclusions The levels of intestinal flora in patients with AC is closely related to the occurrence of anxiety and depression.The scores of NRS and ISI and concomitant diseases are closely related to the occurrence of emotional abnormalities in patients with AC.
万方数据
维普
