Role of oxidative stress-related pathways in doxorubicin-induced cardiomyopathy
Doxorubicin(DOX)is a potent chemotherapy drug commonly used alone or in combination to treat a variety of cancers.However,its clinical application may lead to severe cardiotoxicity.Oxidative stress has been found to play an important role in doxorubicin-induced cardiomyopathy(DIC).This review summarizes the signaling pathways related to oxidative stress in DIC,including Nrf2/Keap1/ARE and Sirt1/p66Shc signaling pathways,and the roles of nitric oxide synthase(NOS),nitric oxide(NOX),and Fe2+in oxidative stress,in an attempt to explain the mechanism of DIC from the perspective of oxidative stress and to provide a theoretical basis or a new way of thinking for the pharmacological research of DIC prevention and treatment.
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