Relationship between level of LECT2 and occurrence of necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia and its clinical significance
Objective To explore the relationship between level of leukocyte derived chemokine 2(LECT2)and occurrence of necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia and its clinical significance,in order to provide a reference for early diagnosis and treatment of Streptococcus pneumoniae pneumonia.Methods The clinical data of 104 children with Streptococcus pneumoniae pneumonia admitted to Xi'an Gaoxin Hospital from January 2022 to January 2024 were retrospectively analyzed.According to the occurrence of necrotizing pneumonia,the children were divided into a necrotizing pneumonia group(49 cases)and a non-necrotizing pneumonia group(55 cases).In the necrotizing pneumonia group,there were 26 boys and 23 girls,aged(7.62±2.58)years.In the non-necrotizing pneumonia group,there were 27 boys and 28 girls,aged(7.18±2.03)years.The levels of LECT2,blood routine[C-reactive protein(CRP),lactate dehydrogenase(LDH),and procalcitonin(PCT)],and cytokines[tumor necrosis factorα(TNF-α)and y interferon(IFN-γ)]were compared between the two groups.The relationship between LECT2 level and necrotizing pneumonia was analyzed,and the influencing factors of necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia were analyzed.The prediction model for necrotizing pneumonia was established and its prediction efficiency was analyzed.x2 test and t test were used.Results There were statistically significant differences between the two groups in terms of the duration of fever,hospital stay,pleural effusion,and pleural thickening(all P＜0.05).The levels of LECT2,CRP,LDH,and PCT in the necrotizing pneumonia group were(28.36±4.46)mg/L,(91.47±7.48)mg/L,(462.27±61.44)U/L,and(0.25±0.10)μg/L,and those in the non-necrotizing pneumonia group were(26.07±5.17)mg/L,(77.65±7.59)mg/L,(346.85±48.93)U/L,and(0.11±0.04)μg/L,with statistically significant differences(t=2.404,9.332,10.649,and 9.564,all P＜0.05).LECT2,CRP,LDH,and PCT were the influencing factors of secondary necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia(all P＜0.05).The area under the curve of LECT2 was 0.636 for predicting secondary necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia,and the area under the curve of the combined detection of all indicators was 0.988,which was of higher diagnostic value.Conclusions The level of LECT2 is closely related to the occurrence of necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia,and its increase may elevate the risk of developing necrotizing pneumonia.Therefore,LECT2 can serve as a potential biomarker for predicting the development of necrotizing pneumonia in children with Streptococcus pneumoniae pneumonia,aiding clinicians in taking more targeted treatment measures at an early stage to improve the prognosis of affected children.
万方数据
维普
