Correlation between serum CCL11 level and T2DM complicated with coronary atherosclerotic heart disease
Objective To investigate the correlation between serum CC chemokine ligand 11(CCL11)level and type 2 diabetes mellitus(T2DM)complicated with coronary atherosclerotic heart disease(CAD).Methods A total of 146 T2DM patients admitted to Shangluo Central Hospital from January 2022 to April 2024 were selected and were divided into a CAD group(70 patients)and a T2DM group(76 patients)according to whether they were complicated with CAD or not.In the CAD group,there were 43 males and 27 females,aged(61.53±8.24)years.In the T2DM group,there were 42 males and 34 females,aged(59.30±6.86)years.The general clinical data of the two groups were collected,and the serum CCL11 level and related metabolic indicators were detected.ttest and x2 test were used.Results The duration of diabetes in the CAD group was longer than that in the T2DM group[(7.41±3.12)years vs.(6.08±2.58)years],and the levels of low density lipoprotein cholesterol(LDL-C)and serum CCL11 were higher than those in the T2DM group[(3.06±1.01)mmol/L vs.(2.60±0.78)mmol/L,(65.53±21.28)ng/L vs.(46.47±18.36)ng/L],with statistically significant differences(t=2.815,3.094,and 5.807,all P＜0.05).Binary logistic regression analysis showed that long duration of diabetes,high LDL-C and serum CCL11 levels were risk factors for CAD in T2DM patients(all P＜0.05).The receiver operator characteristic curve(ROC)analysis showed that the area under the curve(AUC)of serum CCL11 level for diagnosing T2DM with CAD was 0.751,the sensitivity was 65.7％,the specificity was 78.9％,and the Youden index was 0.446.Conclusions Long duration of diabetes,high LDL-C and serum CCL11 levels are independent risk factors for T2DM complicated with CAD.Serum CCL11 level has good diagnostic value in predicting T2DM complicated with CAD.
Type 2 diabetes mellitusCoronary atherosclerotic heart diseaseCCL11CorrelationRisk factors
万方数据
维普
