Efficacy of single nucleotide polymorphisms in predicting the outcomes in patients with chronic hepatitis C treated by direct-acting antivirals
Objective To investigate the efficacy of single nucleotide polymorphisms in predicting the outcomes in patients with chronic hepatitis C(CHC)treated by direct-acting antivirals(DAAs).Methods A total of 112 patients with CHC admitted to Baoji Central Hospital from June 2020 to June 2022 were collected,including 64 males and 48 females,41 cases aged ≥60 years and 61 cases aged＜60 years.All patients were treated with DAAs for 6 months,and IL-28B gene polymorphism was detected before treatment.After treatment,the patients were divided into a response group and a non-response group according to whether there was a virologic response.The IL-28B gene polymorphism of the two groups was compared,and the relationships between prognosis and clinical features of CHC patients were analyzed.The influencing factors of prognosis in CHC patients were analyzed by multivariate logistic regression analysis.The receiver operator characteristic curve(ROC)was drawn to evaluate the predictive efficacies of influencing factors for patients'prognosis.Results Of the 112 CHC patients,89 patients(79.46％)had a virologic response and 23 patients(20.54％)had no response.There were 79 cases(88.76％)of rs8099917TT and 78 cases(87.64％)of rs12979860CC in the response group,and 10 cases(43.48％)and 11 cases(47.82％)in the non-response group,with statistically significant differences(x2=22.969 and 17.754,both P＜0.001).There were 85 cases(95.51％)without fatty liver and 35 cases(39.32％)with Child liver function grade A in the response group,and 17 cases(73.91％)and 6 cases(26.09％)in the non-response group,with statistically significant differences(both P＜0.05).Multivariate logistic regression analysis showed that fatty liver,Child liver function grade C,rs8099917TG,and rs12979860CT were all prognostic factors in CHC patients(RR=4.513,3.666,2.998,and 3.575,all P＜0.05).ROC analysis results showed that fatty liver,Child liver function grade C,rs8099917TG,and rs12979860CT had high value in predicting the prognosis of CHC patients.Conclusion Fatty liver,Child liver function grade C,rs8099917TG,and rs12979860CT are all prognostic factors of CHC patients,and we can guide clinical treatment according to the above indicators.
万方数据
维普
