Expressions of ErbB3 and miR-27a in esophageal cancer tissues and their relationships with clinical prognosis
Objective To investigate the expressions of Erb-B2 receptor tyrosine kinase 3(ErbB3)and microRNA-27A(miR-27a)in esophageal cancer tissues and their relationships with clinical prognosis.Methods A total of 120 patients with esophageal cancer admitted to the Department of Pathology,Yangling Demonstration Zone Hospital from June 2019 to June 2023 were retrospectively selected as the study objects.According to the Glasgow Prognostic Score(GPS),the patients were divided into a good prognosis group(97 cases)and a poor prognosis group(23 cases).Additionally,50 healthy individuals undergoing routine health checks during the same period were selected as controls.The general data were compared between the good prognosis group and the poor prognosis group,and the expressions of ErbB3 and miR-27a were compared between the patients with esophageal cancer and the control group.Logistic regression analysis was used to analyze the factors influencing prognosis in patients with esophageal cancer,and a nomogram was constructed.Spearman correlation analysis was used to analyze the correlations between ErbB3 and miR-27a and prognosis.The predictive efficacies of ErbB3 and miR-27a for prognosis in patients with esophageal cancer were analyzed by the receiver operating characteristic curve(ROC).Independent sample t test,ANOVA,and x2 test were used.Results There were 55 males and 42 females in the good prognosis group,aged 47-68 years.There were 14 males and 9 females in the poor prognosis group,aged 45-66 years.The proportions of the patients with stage Ⅲ tumors and lymph node metastasis in the poor prognosis group were higher than those in the good prognosis group,and the proportion of the patients with low differentiation was lower than that in the good prognosis group(all P＜0.05).The expression levels of ErbB3[(1.59±0.45)]and miR-27a[(2.59±0.95)]in the poor prognosis group were higher than those in the good prognosis group[(1.28±0.37)and(1.84±0.52)]and the control group[(0.72±0.28)and(0.85±0.33)],and those in the good prognosis group were higher than those in the control group(all P＜0.05).Logistic regression analysis showed that tumor stage,degree of differentiation,lymph node metastasis,and expressions of ErbB3 and miR-27a were all prognostic factors in patients with esophageal cancer(all P＜0.05).Spearman correlation analysis showed that the expressions of ErbB3 and miR-27a in patients with esophageal cancer were positively correlated with GPS(r=0.294 and 0.282,P=0.001 and 0.002).ROC analysis results showed that the area under the curve(AUC)predicted by ErbB3 combined with miR-27a was greater than that predicted by ErbB3 or miR-27a alone(0.873 vs.0.715 and 0.715).Conclusion The expressions of ErbB3 and miR-27a in esophageal cancer tissues have significant prognostic value for patients with esophageal cancer.
万方数据
维普
