Observation on the effects of fumigation and steaming with Yiqi Wenjing Huoxue Prescription on oxaliplatin induced peripheral neurotoxicity and TCM syndromes in patients with colorectal cancer undergoing adjuvant chemotherapy after surgery
Objective To explore the effects of fumigation and steaming with Yiqi Wenjing Huoxue Prescription on oxaliplatin induced peripheral neurotoxicity and traditional Chinese medicine(TCM)syndromes in patients with colorectal cancer undergoing adjuvant chemotherapy after surgery.Methods This study was a randomized controlled trial.A total of 91 patients with colorectal cancer requiring adjuvant chemotherapy after surgery were selected from March 2022 to March 2024 in the Department of Traditional Chinese and Western Medicine Oncology,the Second Affiliated Hospital of PLA Air Force Military Medical University.The patients were divided into a treatment group(46 cases)and a control group(45 cases)by the random number table method.A total of 8 cases fell off,and 42 cases were finally included in the treatment group and 41 cases in the control group.There were 23 males and 19 females in the treatment group,aged(52.37±5.25)years,and the pathological staging was stage Ⅱ in 11 cases and stage Ⅲ in 31 cases.There were 22 males and 19 females in the control group,aged(54.21±5.23)years,and the pathological staging was stage Ⅱ in 12 cases and stage Ⅲ in 29 cases.The control group was treated with XELOX regimen chemotherapy[oxaliplatin(intravenous infusion)combined with capecitabine(oral)],and the treatment group was given fumigation and steaming with Yiqi Wenjing Huoxue Prescription on the basis of the control group.Both groups were treated for 6 cycles,with 21 d as a cycle.The incidence of peripheral neurotoxicity,toxicity grading,TCM syndrome score,and levels of serum inflammatory factors[superoxide dismutase(SOD)and nerve growth factor(NGF)]were compared between the two groups.Independent sample t test,paired t test,x2 test,and rank sum test were used.Results At the 4th and 6th cycle,the incidence of peripheral neurotoxicity in the treatment group[57.1％(24/42)and 66.7％(28/42)]was lower than that in the control group[92.6％(38/41)and 97.5％(40/41)](both P＜0.05).After 4 and 6 cycles of treatment,the degree of peripheral neurotoxicity in the treatment group was better than that in the control group(Z=-5.051,P＜0.001;Z=-5.276,P＜0.001).After 6 cycles of treatment,the levels of SOD[(69.63±9.11)kU/L]and NGF[(176.21±26.79)ng/L]in the treatment group were higher than those in the control group[(55.23±8.77)kU/L and(139.24±21.78)ng/L],and the TCM syndrome score[(6.62±1.31)points]was lower than that in the control group[(8.94±2.97)points](all P＜0.05).Conclusion The application of fumigation and steaming with Yiqi Wenjing Huoxue Prescription can reduce the oxaliplatin induced peripheral neurotoxicity and improve the TCM syndromes in patients with colorectal cancer undergoing adjuvant chemotherapy after surgery.
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