Study on the curative effect of acupotomy on lumbar degenerative disease based on quantitative magnetic resonance imaging
Objective To explore the value of quantitative magnetic resonance imaging(MRI)in evaluating the efficacy of acupotomy in the treatment of lumbar degenerative disease.Methods A total of 71 patients with lumbar degenerative disease admitted to Dongguan Wanjiang Hospital from October 2021 to August 2023 were selected as the study objects,including 50 males and 21 females,aged 38-76(52.14±3.48)years,with a disease course of 2-17(10.75±1.42)years.All patients were treated with acupotomy once a week,and the treatment was withdrawn if it was ineffective for 3 consecutive times.Before and after treatment,the patients underwent quantitative MRI,including delayed gadolinium-enhanced MRI of cartilage(dGEMRIC)and T2 mapping.The MRI results were analyzed,and the glucosaminoglucide(GAG)concentration,proteoglycan content,and T1 and T2 relaxation time were compared before and after treatment.Paired t test and analysis of variance were used.Results On MRI,there were 32 cases of annulus fibrosis degeneration,and 20 cases of lumbar vertebrae showed banded and flacy-like hypersignal on T2WI.In 27 cases,the necrotic cells in the nucleus pulposus were debris and reactive hyperplasia,and the T1WI showed spotty low signal in the nucleus pulposus.There were 8 cases of annulus fibulation,and T1WI and T2WI showed low signal in the corner of nucleus pulposus.Intervertebral disc cartilaginous endplate degeneration was observed in 4 cases with low signal on T2WI.At 12 h,24 h,and 48 h after treatment,the GAG concentration[(77.21±5.36)mg/L,(84.45±5.84)mg/L,and(90.36±6.48)mg/L]and proteoglycan content[(5.23±0.12)μg/mg,(5.25±0.11)μg/mg,and(5.18±0.13)μg/mg]were higher than those before treatment[(51.15±4.35)mg/L and(1.82±0.21)μg/mg](all P＜0.05).At 12 h,24 h,and 48 h after treatment,the T1 relaxation time[(712.25±58.86)ms,(698.85±57.12)ms,and(684.45±56.89)ms]was longer than that before treatment[(356.52±37.25)ms],and the T2 relaxation time[(49.21±4.36)ms,(47.25±4.11)ms,and(46.23±4.05)ms]was shorter than that before treatment[(77.25±8.15)ms](all P＜0.05).Conclusion Quantitative MRI technique can be used to evaluate the cartilage condition and component changes in patients with lumbar degenerative diseases before and after acupotomy,and the efficacy evaluation is accurate.
Lumbar degenerative diseaseAcupotomyQuantitative magnetic resonance imaging technologyEffect evaluation
万方数据
维普
