Dry eye is a multifactorial ocular surface disease with tear film instability as its core feature.Its incidence rate is increasing year by year.The eye discomfort and visual impairment caused by dry eyes have a serious impact on the patients'work and life.Depression is a common affective disorder,and its incidence rate is also on the rise.Depression has become an important health and social problem at present.Depression is more common in patients with dry eyes than in general population,and dry eyes is also more common in depressed patients.At the same time,antidepressants are also related to the occurrence and development of dry eyes.Therefore,this article summarizes and analyzes these possible related factors,so as to study the correlation between dry eyes and depression and make a brief review.