Value of contrast-enhanced ultrasound,DWI,and serum MAGEA3 and MAGEA4 in diagnosis of papillary thyroid carcinoma
Objective To investigate the value of contrast-enhanced ultrasound(CEUS),diffusion-weighted imaging(DWI),and serum melanoma-associated antigen A3(MAGEA3)and melanoma-associated antigen A4(MAGEA4)in the diagnosis of papillary thyroid carcinoma(PTC).Methods This was a retrospective study.Eighty patients pathologically confirmed with PTC treated at Imaging Center,Ankang Hospital of Traditional Chinese Medicine between January 2022 and March 2024 were selected as a PTC group,including 32 males and 48 females who were(45.84±8.51)years old.Eighty patients with benign thyroid tumors were set as a control group,including 35 males and 45 females who were(44.62±7.50)years old.The serum levels of MAGEA3 and MAGEA4,CEUS characteristics,and apparent diffusion coefficient(ADC)values were compared between the two groups.The consistency of serum MAGEA3 and MAGEA4,CEUS,and DWI with pathological diagnosis was evaluated.t and x2 tests were used for the statistical analysis.Results The serum levels of MAGEA3 and MAGEA4 in the PTC group were higher than those in the control group[(43.68±10.24)ng/L vs.(31.40±6.85)ng/L and(33.57±8.94)ng/L vs.(28.56±6.20)ng/L],with statistical differences(t=8.92 and 4.12;both P＜0.05).The proportions of the patients with lymph node enlargement,calcification,heterogeneous echogenicity,unclear boundaries,and irregular shapes in the PTC group were higher than those in the control group[20.00％(16/80)vs.3.75％(3/80),60.00％(48/80)vs.21.25％(17/80),58.75％(47/80)vs.35.00％(28/80),47.50％(38/80)vs.18.75％(15/80),and 72.50％(58/80)vs.28.75％(23/80)],with statistical differences(x2=10.09,24.90,9.06,14.93,and 30.63;all P＜0.05).Blood flow grading in the PTC group was mainly Ⅱ-Ⅲ,and that in the control group was mainly Ⅰ-Ⅱ,with a statistical difference between the two groups(Z=44.91;P＜0.05).The ADC value in the PTC group was significantly lower than that in the control group[(1.26±0.33)× 10 3mm2/s vs.(1.93±0.64)×10-3mm2/s],with a statistical difference(t=8.32;P＜0.05).The results of the receiver operating characteristic curve analysis showed that the sensitivities of CEUS,ADC,MAGEA3,and MAGEA4 in the diagnosis of PTC were 83.8％,93.8％,68.8％,and 53.7％,respectively;the specificities were 90.0％,66.2％,91.2％,and 85.0％,respectively;the areas under the curves(AUC)were 0.937,0.819,0.839,and 0.690,respectively.These findings demonstrate the high diagnostic accuracy of these indicators for PTC.When CEUS,ADC,MAGEA3,and MAGEA4 were combined,the sensitivity,specificity,AUC were 96.3％,93.8％,and 0.990,respectively.Conclusions Serum levels of MAGEA3 and MAGEA4 are elevated in patients with PTC.The combination of CEUS,DWI,and serum MAGEA3 and MAGEA4 has high clinical application value in the diagnosis of PTC and can improve diagnostic accuracy.
Contrast-enhanced ultrasoundDiffusion-weighted imagingMelanoma-associated antigen A3Melanoma-associated antigen A4Papillary thyroid carcinomaDiagnostic value
万方数据
维普
