Objective To analyze the influencing factors of the effect of vitrectomy combined with scleral buckling in the treatment of patients with open eyeball injury.Methods A total of 167 patients with open eyeball injury treated at Department of Ophthalmology,Lianyungang First People's Hospital from January 2020 to July 2023 were selected as the study objects,including 176 males and 38 females.They were 25-59(42.04±8.10)years old.All the patients underwent vitrectomy and scleral buckling surgery,and were divided into an effective treatment group and an ineffective treatment group based on the treatment effect.x2 test and t test were used for the statistical analysis.Multivariate logistic regression was used to analyze the influencing factors of vitrectomy combined with scleral buckling in the treatment of the patients with open eyeball injury.Results Among the 167 patients,106 were effectively treated,with an effective rate of 63.47%(106/167).They were included in the treatment effective group.The rest 61 patients were ineffective,with an ineffective rate of 36.53%(61/167).They were included in the treatment ineffective group.The proportion of preoperative best corrected visual acuity(BCVA)<0.1,the proportion of injury zone Ⅲ,the proportion of injury type of intraocular foreign bodies,and the incidence rate of endophthalmitis in the treatment ineffective group were higher than those in the effective treatment group[68.85%(42/61)vs.49.06%(52/106),26.23%(16/61)vs.12.26%(13/106),52.46%(32/61)vs.33.02%(35/106),and 54.10%(33/61)vs.33.96%(36/106);the proportion of surgery timing between 7-14 d in the treatment ineffective group was lower than that in the treatment effective group[77.05%(47/61)vs.91.51%(97/106)];the length of the wound in the treatment ineffective group was longer than that in the treatment effective group[(4.21±0.42)mm vs.(3.96±0.36)mm];there were statistical differences(x2=6.17,6.92,7.02,6.48,and 6.83;t=4.06;all P<0.05).The multivariate logistic regression analysis showed that preoperative BCVA<0.1(OR=2.174,95%CI 1.012-4.672),wound length(OR=5.224,95%CI 1.936-14.100),injury zone Ⅲ(OR=4.064,95%CI 1.517-10.884),injury type of intraocular foreign bodies(OR=3.236,95%CI 1.425-7.350),and endophthalmitis(OR=2.879,95%CI 1.346-6.161)were the risk factors for the effect of vitrectomy combined with scleral buckling in the treatment of the patients with open globe injury;the surgery timing between 7-14 d(OR=0.225,95%CI 0.064-0.788)was a protective factor for the effect of vitrectomy combined with scleral buckling in the treatment of the patients with open eyeball injury(all P<0.05).Conclusion Preoperative BCVA,wound length,injury zone,injury type,endophthalmitis,and surgery timing are the influencing factors for the effect of vitrectomy combined with scleral buckling in the treatment of patients with open eyeball injury.