Value of contrast-enhanced ultrasound combined with MSCT in diagnosis of liver cirrhosis complicated with small liver cancer
Objective To evaluate the value of contrast-enhanced ultrasound(CEUS)combined with multi-slice spiral CT(MSCT)in the diagnosis of cirrhosis complicated with small liver cancer.Methods The clinical data of 97 patients with cirrhosis and focal lesions treated at Xincheng District Hospital of Traditional Chinese Medicine from October 2021 to October 2023 were retrospectively analyzed.According to the pathological results,they were divided into an observation group(52 patients with cirrhosis and small liver cancer)and a control group(45 patients with cirrhosis hyperplasia nodules).In the observation group,there were 30 males and 22 females;they were(45.87±6.74)years old;their lesion size was(1.95±0.37)cm;Child liver function classification:43 cases were grade A,and 9 cases were grade B.In the control group,there were 27 males and 18 females;they were(46.91±7.62)years old;their lesion size was(1.89±0.35)cm;Child liver function classification:40 cases were grade A,and 5 cases were grade B.All the patients underwent CEUS examination and MSCT examination.Pathological examination was used as the gold standard to analyze the consistency of CEUS,MSCT,and their combination with the gold standard in the diagnosis of cirrhosis complicated with small liver cancer.The diagnostic values of CEUS,MSCT,and the combination of CEUS and MSCT for diagnosing cirrhosis complicated with small liver cancer were analyzed.t test and x2 test were used for the statistical analysis.Results CEUS was consistent with the gold standard in the diagnosis of cirrhosis complicated with small liver cancer in some degree(Kappa=0.628;P＜0.05).CEUS combined with MSCT was consistent with gold standard in the diagnosis of cirrhosis complicated with small liver cancer(Kappa=0.855;P＜0.05).The regional blood volumes(RBV)in the delayed stage and portal vein stage in the observation group were lower than those in the control group[(472.68±49.83)ml vs.(745.21±78.16)ml and(1 257.61±138.94)ml vs.(1 485.79±186.27)ml;both P＜0.05].The arterial regional blood flower(RBF)and RBV in the arterial stage in the observation group were higher than those in the control group[(65.96±7.67)ml vs.(46.12±4.83)ml and(3 472.97±458.21)ml vs.(1 526.58±272.30)ml;both P＜0.05];there were no statistical differences in RBF in the delay stage and portal vein stage between the two groups(both P＞0.05).The peak intensity(PI)in the observation group was higher than that in the control group(64.81±7.62 vs.53.20±5.45;P＜0.05);the time to peak(TTP)and arrival time(AT)in the observation group were shorter than those in the control group[(28.19±4.65)s vs.(63.41±7.93)s and(14.26±4.82)s vs.(19.78±5.84)s;both P＜0.05).There were no statistical differences in the CT values in the delayed stage and plain scan stage between the two groups(both P＞0.05).The CT value in the portal vein stage in the observation group was lower than that in the control group(62.45±6.74 vs.83.21±8.95;P＜0.05).The CT value in the arterial stage in the observation group was higher than that in the control group(108.49±11.92 vs.65.38±7.21;P＜0.05).The areas under the curves(AUC)of CEUS,MSCT,and their combination in the diagnosis of cirrhosis complicated with small liver cancer were 0.815,0.845,and 0.928,respectively;the AUC of their combination was higher(P＜0.05).Conclusion CEUS and MSCT have some value in the diagnosis of cirrhosis complicated with small liver cancer,and their combination has higher diagnostic value.
Contrast-enhanced ultrasoundMulti-slice spiral CTLiver cirrhosisSmall liver cancerDiagnostic value
万方数据
维普
