Effect of fumigation with Shire Duqing decoction combined with diphenyl cream for patients with perianal eczema
Objective To explore the effect of fumigation with Shire Duqing decoction combined with diphenyl cream for patients with perianal eczema.Methods One hundred and ninety-six patients with perianal eczema treated at Xi'an Daxing Hospital from January 2022 to July 2023 selected for the randomized controlled trial,and were divided into an observation group and a control group by the random number table method,with 98 cases in each group.There were 51 males and 47 females in the control group;they were(39.15±5.26)years old;their disease course was(5.78±1.62)weeks.There were 46 males and 52 females in the observation group;they were(37.82±5.08)years old;their disease course was(5.41±1.38)weeks.The control group were treated with diphenyl cream.The observation group were treated with diphenyl cream and fumigation with Shire Duqing decoction.After 3 weeks'treatment,the severities of eczema,scores of traditional Chinese medicine syndromes,levels of inflammation and immune factors[interleukin-4(IL-4),interferon gamma(INF-y),and immunoglobulin E(IgE)],quality of life and psychological resilience,efficacies,adverse reactions,and recurrence rates were compared between the two groups.x2 and t tests were used.Results The treatment effective rate of the observation group was higher than that of the control group[94.90％(93/98)vs.83.67％(82/98)],with a statistical difference(x2=6.453,P=0.011).After the treatment,the scores of anal itching,eczema area,perianal exudate,main symptoms,and secondary syndromes,the levels of IL-4,INF-γ,and IgE,and the scores of Dermatology Life Quality Index(DLQI)and Connor-Davidson Resilience Scale(CD-RISC)in the observation group were better than those in the control group[1.44±0.31 vs.1.61±0.33,1.47±0.21 vs.1.59±0.34,1.39±0.29 vs.1.52±0.41,6.21±1.83 vs.7.59±1.73,2.57±0.43 vs.3.16±0.51,2.07±0.35 vs.2.41±0.29,(30.62±4.83)ng/L vs.(34.91±5.27)ng/L,(35.14±5.71)ng/L vs.(32.56±4.95)ng/L,(561.34±79.62)U/ml vs.(584.28±61.37)U/ml,6.04±1.51 vs.7.72±1.39,and 67.34±7.21 vs.62.48±6.05],with statistical differences(all P＜0.05).The recurrence rate of the observation group was lower than that of the control group[14.29％(14/98)vs.29.59％(29/98)],with a statistical difference(x2=6.703,P=0.010).No serious adverse reactions were observed in both groups.Conclusion Shire Duqing decoction combined with diphenyl cream for patients with perianal eczema can alleviate their symptoms,such as itching and skin lesions,inhibit inflammatory reactions,improve therapeutic effect,and reduce the recurrence rate.
万方数据
维普
