Modified Xiao Jianzhong decoction in treatment of patients with centrally mediated abdominal pain syndrome of spleen and stomach deficiency-cold type
Objective To observe the clinical efficacy of modified Xiao Jianzhong decoction for patients with centrally mediated abdominal pain syndrome(CAPS)of spleen and stomach deficiency-cold type.Methods Sixty-eight patients with CAPS of spleen and stomach deficiency-cold type treated at Baoji Chencang Hospital from September 2021 to August 2023 were selected for the randomized controlled trial,and were divided into a control group and an observation group by the random number table method,with 34 cases in each group.There were 18 males and 16 females in the control group;they were(49.97±9.35)years old;their disease course was from 6 months to 8 years.There were 15 males and 19 females in the observation group;they were(51.68±11.83)years old;their disease course was from 6 months to 10 years.The control group were given routine clinical treatment,such as regulating intestinal function,antispasmodic,probiotics to regulate intestinal flora,etc.and took doxorubicin for anxiolytic treatment.The observation group took Xiao Jianzhong decoction.The scores of pain scale and Hamilton Anxiety Scale(HAMA),life quality,therapeutic effects,and adverse reactions were compared between the two groups.t and x2 tests were used for the statistical analysis.Results After 4 weeks'treatment,the scores of pain scale and HAMA in the observation group were lower than those in the control group(2.47±0.83 vs.4.03±1.00 and 6.26±2.26 vs.9.21±2.19;both P＜0.05).The effective rate in the observation group was higher than that in the control group[94.12％(32/34)vs.73.53％(25/34);P=0.021].The incidence rate of adverse reactions in the observation group was lower than that in the control group[17.65％(6/34)vs.76.47％(26/34);P＜0.05].The score of life quality in the observation group was higher than that in the control group(88.94±1.59 vs.79.56±2.05;P＜0.05).Conclusion Modified Xiao Jianzhong decoction for patients with CAPS of spleen and stomach deficiency-cold type can effectively alleviate their symptoms,improve their life quality,with better overall effectiveness and a lower incidence rate of adverse reactions.
万方数据
维普
