Clinical effect analysis of dual antiplatelet drugs combined with Chinese medicine in the treatment of progressive ischemic stroke
Objective To investigate the clinical effect of ozagrel trometamol and clopidogrel bisulfate dual antiplatelet therapy combined with traditional Chinese medicine in the treatment of progressive ischemic stroke.Methods A total of 100 patients with progressive ischemic stroke without intravenous thrombolysis or intravascular thrombolysis were selected from Guangdong Sanjiu Brain Hospital from January 2022 to January 2023.The patients were divided into a control group(50 cases)and an experimental group(50 cases)by the random number table method.There were 23 males and 27 females in the experimental group,aged(62.21±10.77)years.There were 26 males and 24 females in the control group,aged(60.52±11.27)years.The control group was treated with clopidogrel bisulfate+ginkgo diterpene lactone meglumine,and the experimental group was treated with ozagrel trometamol on the basis of the control group.Both groups were treated for 14 days.The scores of National Institutes of Health Stroke Scale(NIHSS)and Barthel index(BI)of daily living ability before and after treatment,treatment effect,and occurrence of adverse drug reactions during treatment were compared between the two groups.Independent sample t test,paired t test,and x2 test were used for statistical analysis.Results After treatment,the NIHSS score of the experimental group was lower than that of the control group[(16.62±3.07)points vs.(21.13±3.27)points],and the BI score of the experimental group was higher than that of the control group[(90.17±7.25)points vs.(84.41±7.05)points](both P＜0.05).The total effective rate of the experimental group was higher than that of the control group[90.00％(45/50)vs.50.00％(25/50)](P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups[4.00％(2/50)vs.0](P＞0.05).Conclusion Ozagrel trometamol and clopidogrel bisulfate dual antiplatelet therapy combined with traditional Chinese medicine has a good effect on the treatment of progressive ischemic stroke,which has reference significance for the clinical treatment of progressive ischemic stroke.
万方数据
维普
