国际医药卫生导报2024,Vol.30Issue(24) :4101-4106.DOI:10.3760/cma.j.issn.1007-1245.2024.24.008

Wnt/β-catenin信号通路对阿尔茨海默病发病机制的研究进展

Research progress on the role of Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer's disease

康国伟 李潇 赵瑞清 冯波
国际医药卫生导报2024,Vol.30Issue(24) :4101-4106.DOI:10.3760/cma.j.issn.1007-1245.2024.24.008

Wnt/β-catenin信号通路对阿尔茨海默病发病机制的研究进展

Research progress on the role of Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer's disease

康国伟 1李潇 1赵瑞清 1冯波1
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作者信息

  • 1. 滨州医学院附属医院神经内科,滨州 256600
  • 折叠

摘要

阿尔茨海默病(AD)是一种中枢神经系统退行性疾病,发病机制复杂多样.在AD中,Wnt/β-catenin信号通路的激活可调节炎症反应、改善突触功能和抗氧化应激.Wnt/β-catenin信号通路可能成为治疗AD的新靶点,为AD治疗提供新的研究方向.

Abstract

Alzheimer's disease(AD)is a degenerative disease of the central nervous system,whose pathogenesis is complex and diverse.The activation of the Wnt/β-catenin signaling pathway plays a key role in regulating inflammatory responses,improving synaptic function,and anti-oxidative stress in AD.This article elaborates that the Wnt/β-catenin signaling pathway may become a new therapeutic target for AD,providing a new research direction for the treatment of AD in the future.

关键词

Wnt/β-catenin信号通路/阿尔茨海默病/发病机制/神经系统疾病/进展

Key words

Wnt/β-catenin signaling pathway/Alzheimer's disease/Pathogenesis/Neurological disorders/Progress

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出版年

2024
国际医药卫生导报
中华医学会,国际医药卫生导报社

国际医药卫生导报

影响因子:0.781
ISSN:1007-1245
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