Investigation on medication rules of traditional Chinese medicine in the treatment of steroid-induced osteonecrosis of the femoral head based on data mining
Objective To analyze the medication rules of traditional Chinese medicine(TCM)in the treatment of steroid-induced osteonecrosis of the femoral head(SONFH),in order to provide theoretical support and reference for the clinical medication of SONFH.Methods The relevant literatures on the treatment of SONFH with TCM were searched in the National Knowledge Infrastructure Database(CNKI)and WanFang Data Knowledge Service Platform(WanFang)from July 2005 to July 2024,and the TCM included in the prescriptions was processed and standardized.WPS table,SPSS Statistics 25.0,SPSS Modeler18.0,and other software were used to analyze the drug frequency,property-flavor-meridians,association rules,and cluster analysis of TCM in the treatment of SONFH.Results A total of 410 relevant literatures were searched and 31 were included.A total of 36 prescriptions were selected,involving 101 kinds of TCM,mainly involving 4 flavors,3 properties,12 meridians,and 17 drug categories.High frequency drugs included angelica sinensis,Astragalus membranaceus,Salvitis miltiorrhiza,Chuanxiong,Rehmannia Rehmannia,Achyranthes ulcommia,bone crushing supplement,Tuckaia poria,teasel root and so on.The medicinal properties were mainly warm,flat,and mild,and the flavors were mainly sweet,xin,bitter,and salty.The main meridians were liver meridian,kidney meridian,spleen meridian,heart meridian,and lung meridian.Efficacy categories of tonifying vacuity drugs,promoting blood circulation and removing blood stasis drugs,wind-dampness drugs were more common.Association rules obtained"Chuanxiong-Angelica","Achyranthus-Angelica","drynaria rhizome-Angelica","Eucommia-Angelica",and other core drug pairs.The cluster analysis classified the drugs into 6 categories.Conclusions The main pathogenesis of SONFH is kidney deficiency,phlegm dampness,and blood stasis.The treatment principle is"warming meridians and clearing collaterals,activating blood and relieving pain,tonifying liver and kidney,invigorating spleen and removing dampness".The main drugs used are warm,flat,and mild warm.The main meridian involved is liver meridian,followed by kidney meridian,spleen meridian,heart meridian,and lung meridian.The main therapeutic drugs are tonifying deficiency,promoting blood circulation and removing blood stasis,dispelling wind-dampness and rehydrating dampness.
Steroid-induced osteonecrosis of the femoral headTraditional Chinese medicineData miningMedication rules
万方数据
维普
