Relationships between serum SCUBE1 and Sestrin2 levels and microvascular obstruction in patients with acute ST segment elevation myocardial infarction after PCI
Objective To investigate the relationships between serum signal peptide CUB epidermal growth factor domain containing protein-1(SCUBE1)and Sestrin2 levels and microvascular obstruction in patients with acute ST segment elevation myocardial infarction(ASTEMI)after percutaneous coronary intervention(PCI).Methods The medical records of 182 ASTEMI patients treated in Xi'an Central Hospital from July 2021 to June 2023 were retrospectively analyzed.All the patients underwent PCI after admission,and serum SCUBE1 and Sestrin2 levels were detected by enzyme-linked immunosorbent assay(ELISA)before surgery.One week after surgery,the microvascular occlusion was evaluated by cardiac magnetic resonance examination(MRI),and the patients were divided into an occurrence group and a non-occurrence group.The risk factors of microvascular obstruction in ASTEMI patients after PCI were screened by the logistic regression model,and the efficacy of serum SCUBE1 and Sestrin2 in predicting microvascular obstruction in ASTEMI patients after PCI were evaluated by the receiver operating characteristic curve(ROC).Independent sample t test and x2 test were used for statistical analysis.Results Among 182 patients with ASTEMI treated by PCI,72 patients had microvascular occlusion,with an incidence of 39.56％.In the occurrence group,there were 42 males and 30 females,aged(53.06±7.51)years,with a body mass index of(23.61±0.94)kg/m2.In the non-occurrence group,there were 69 males and 41 females,aged(52.79±6.68)years,with a body mass index of(23.73±0.86)kg/m2.The left ventricular ejection fraction in the occurrence group was lower than that in the non-occurrence group,and the infarct size,troponin T,serum SCUBE1,and serum Sestrin2 were higher than those in the non-occurrence group(all P＜0.05).Logistic regression analysis showed that left ventricular ejection fraction(OR=0.271,95％CI:0.117-0.627),infarct size(OR=4.651,95％CI:2.009-10.764),troponin T(OR=3.773,95％CI:1.630-8.733),serum SCUBE1(OR=4.491,95％CI:1.943-10.171),and serum Sestrin2(OR=4.358,95％CI:1.882-10.087)were influencing factors for microvascular obstruction in ASTEMI patients after PCI(all P＜0.05).The sensitivities,specificities,and areas under the curves of serum SCUBE1 and Sestrin2 alone and combined for microvascular obstruction in ASTEMI patients after PCI were 0.719,0.783,0.801,0.800,0.725,0.824,0.771(95％CI:0.674-0.867),0.764(95％CI:0.669-0.860),and 0.882(95％CI:0.815-0.948),respectively.Conclusion Serum SCUBE1 and Sestrin2 can be used to predict the occurrence of coronary microvascular occlusion in patients with ASTEMI after PCI,with good predictive efficacy.
万方数据
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