Relationships between monocyte chemotactic protein 1 and periosteal protein levels and prognosis in patients with acute myocardial infarction after PCI
Objective To evaluate the relationships between monocyte chemotactic protein-1(MCP-1)and periosteal protein levels and prognosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods In this study,106 patients with AMI who underwent PCI in Xingyuan Hospital of Yulin from March 2021 to January 2024 were included.Based on the occurrence of major adverse cardiovascular events(MACE)within 3 months after surgery,the patients were divided into a poor prognosis group and a good prognosis group.The levels of MCP-1 and periosteal protein were measured by enzyme-linked immunosorbent assay(ELISA)after PCI,and the levels of MCP-1 and periosteal protein in patients with different prognosis were compared.Spearman rank correlation analysis and logistic regression model were used to analyze the correlations between MCP-1 and periosteal protein levels and prognosis in AMI patients after PCI.The receiver operating characteristic curve(ROC)was drawn to analyze MCP-1 and periosteal protein in predicting the prognosis in AMI patients after PCI.Independent sample t test and x2 test were used for statistical analysis.Results In the good prognosis group,there were 44 males and 31 females,aged(65.43±5.76)years,with a body mass index of(23.07±0.97)kg/m2.In the poor prognosis group,there were 19 males and 12 females,aged(65.02±5.41)years,with a body mass index of(22.86±0.86)kg/m2.The levels of MCP-1 and periosteal protein in the poor prognosis group were higher than those in the good prognosis group[(35.57±3.65)ng/L vs.(29.66±3.52)ng/L,(155.12±12.19)μg/L vs.(142.03±10.43)μg/L],with statistically significant differences(both P＜0.05).Correlation analysis showed that both MCP-1 and periosteal protein were positively correlated with poor prognosis(r=0.594 and 0.444,both P＜0.05).Logistic regression analysis showed that both MCP-1 and periosteal protein were risk factors for poor prognosis(OR=1.615 and 1.119,both P＜0.05).ROC analysis showed that the areas under the curves(AUCs)of MCP-1 and periosteal protein alone were 0.877 and 0.782,respectively.When MCP-1 and periosteal protein were used in combination,the AUC increased to 0.929,the sensitivity and specificity were 87.1％and 86.7％,respectively,and the Yoden index was 0.738.Conclusions MCP-1 and periosteal protein levels are closely related to the prognosis of AMI patients after PCI,and can be used as biomarkers for predicting poor prognosis.These findings support the use of MCP-1 and periosteal protein as potential tools for assessing risk and treatment response in AMI patients in clinical practice.
Acute myocardial infarctionPercutaneous coronary interventionMonocyte chemotactic protein 1Periosteal proteinPrognosis
万方数据
维普
