Detection and significance of IL-26 and Th17/Treg in patients with psoriasis vulgaris
Objective To investigate the levels of serum interleukin-26(IL-26)and peripheral blood helper T cell 17/regulatory T cells(Th17/Treg)in patients with psoriasis vulgaris,and analyze the clinical significance of detection.Methods A total of 100 patients with psoriasis vulgaris admitted to Ankang Hospital of Traditional Chinese Medicine from December 2020 to December 2023 were retrospectively selected,and 50 cases of chronic skin diseases and 50 healthy subjects(control group)admitted to Ankang Hospital of Traditional Chinese Medicine during the same period were selected in the ratio of 2:1 for a control study.The differences in baseline data such as gender and age as well as levels of IL-26 and Th17/Treg among the groups were analyzed.The influencing factors of psoriasis vulgaris were analyzed by binary logistic regression analysis,and the diagnostic efficacies of IL-26 and Th17/Treg levels in psoriasis vulgaris were analyzed by the receiver operating characteristic curve(ROC).The relationships between Psoriasis Area and Severity Index(PASI)score and levels of IL-26 and Th17/Treg were analyzed.x2 test,t test,and variance analysis were used.Results There was no statistically significant difference in the gender,age,body mass index,smoking rate,or drinking rate among the three groups(all P＞0.05).There was no statistically significant difference in the course of disease between the psoriasis vulgaris group and chronic skin disease group(P＞0.05).The levels of IL-26,Th17,Treg,and Th17/Treg were(641.82±192.05)ng/L,(5.36±1.34)％,(3.09±0.91)％,and 1.83±0.55 in the psoriasis vulgaris group,(571.15±155.31)ng/L,(4.58±1.06)％,(3.81±1.19)％,and 1.28±0.38 in the chronic skin disease group,(504.46±122.51)ng/L,(3.93±0.88)％,(5.14±1.51)％,and 0.81±0.24 in the control group,with statistically significant differences(F=11.535,26.054,52.482,and 90.638,all P＜0.05).Binary logistic regression analysis showed that both IL-26 and Th17/Treg levels were risk factors for psoriasis vulgaris(both P＜0.05).ROC analysis showed that the areas under the curves(AUCs)of IL-26 and Th17/Treg levels in the diagnosis of psoriasis vulgaris were 0.700 and 0.891,respectively.IL-26 and Th17/Treg levels were included in the regression equation,and the model data were obtained.The AUC,sensitivity,and specificity of the model data for diagnosing psoriasis vulgaris were 0.912,0.920,and 0.790.Linear regression analysis results showed that IL-26,Th17,Treg,and Th17/Treg were significantly correlated with PASI in psoriasis vulgaris patients(all P＜0.05).Conclusions Serum IL-26 and Th17/Treg are elevated in patients with psoriasis vulgaris.IL-26 and Th17/Treg have some value in diagnosing psoriasis vulgaris,the combined model has a higher diagnostic value.The levels of IL-26 and Th17/Treg correlate closely with the severity of psoriasis vulgaris.
Psoriasis vulgarisInterleukin-26Helper T cell 17Regulatory T cells
万方数据
维普
