Analysis of Pathogenic Bacteria and Drug Resistance in Children with Acute Osteomyelitis in Shandong Province
Objective To summarize the results of pus-culture and drug sensitivity in children with acute osteomyelitis in Children's Hospital Affiliated to Shandong University and to provide reference for clinical antibiotic use.Methods The data of 115 children with acute osteomyelitis diagnosed and treated from January 2018 to January 2023 were retrospectively analyzed,including 71 cases of boys and 44 cases of girls,aged from 19 days to 15 years.The results of pus-culture and drug sensitivity were summarized and analyzed.Results Of the 115 children,53 were infected with methicillin-sensitive Staphylococcus aureus(MSSA),33 with methicillin-resistant Staphylococcus aureus(MRSA),2 with Streptococcus pneumoniae,1 with Salmonella enteritidis,1 with Haemophilus influenzae,and 25 were negative.Among the 53 cases of MSSA,51 were resistant to ampicillin,42 to clindamycin,41 to erythromycin,and only 1 to gentamicin.All the children were resistant to penicillin and sensitive to amoxicillin,cefoxitin,benzacillin,vancomycin and linezolid.Among the 33 cases of MRSA,27 cases were resistant to clindamycin,27 to erythromycin,and 3 to gentamicin.All the children were resistant to ampicillin,amoxicillin,cefoxitin,benzacillin and penicillin,and sensitive to vancomycin and linezolid.Conclusion Staphylococcus aureus is the main causative agent of acute osteomyelitis in children,and all are susceptible to vancomycin and linezolid.MSSA has a high resistance rate to ampicillin,clindamycin and erythromycin.
万方数据
维普
