肝细胞内Ca2+信号与肝脏再生和肝脏疾病的联系
Association of intracellular calcium signaling with liver regeneration and disease
郝永乐 1邹仁哲 2韩静雯 3陈菲 4唐建红4
作者信息
- 1. 赣南医科大学基础医学院
- 2. 赣南医科大学第一临床医学院
- 3. 赣南医科大学康复学院
- 4. 赣南医科大学赣州市实验动物工程技术研究中心,江西 赣州 341000
- 折叠
摘要
肝脏作为人体内新陈代谢中心,参与了机体的营养代谢、血容量调节、免疫功能调节、内分泌调节、脂质和胆固醇稳态维持以及异生型化合物的分解等过程,是人体最重要的器官之一.肝脏也是机体中唯一具有强大再生能力的内部器官.肝脏再生过程受到细胞质钙离子(Ca2+)、细胞核Ca2+和线粒体内Ca2+的影响.病毒感染、长期酗酒和长期使用药物等所导致的严重、慢性损伤会使肝脏再生能力失调,并导致肝瘢痕和肝硬化等.已有研究表明,肝脏细胞Ca2+浓度参与调节肝脏的胆汁分泌、脂质代谢、细胞增殖和细胞凋亡等过程.肝脏再生过程中,肝细胞增殖受到Ca2+动员激动剂胰岛素的影响,胰岛素通过影响细胞核Ca2+参与调控肝细胞增殖;此外,线粒体Ca2+通过抑制细胞凋亡调节肝细胞增殖.当慢性病毒性肝炎发生时,肝细胞膜通透性增强导致细胞质Ca2+增多,病毒通过调节Ca2+信号传导途径促进病毒自身复制.本综述阐述了肝细胞内Ca2+信号与肝脏再生和不同肝脏疾病的联系.
Abstract
The liver is a vital organ in the human body,serving as the metabolic center and performing various functions,such as regulating nutrient metabolism,blood volume,immune function,endocrine regulation,maintaining lipid and cholesterol homeostasis,and decomposing heterologous compounds.The liver has a unique ability to regenerate itself,making it the only internal organ in the body capable of recovering from most injuries.Cytoplasmic calcium ions(Ca2+),nuclear Ca2+ and mitochondrial Ca2+contribute to the liver regeneration process.However,the serious and chronic damage by viral infection,long-term alcoholism and medication use will cause dysfunction of liver regeneration ability and lead to liver scarring and cirrhosis,etc.Previous studies have shown that Ca2+ concentration in liver cells plays a significant role in regulating bile secretion,lipid metabolism,cell proliferation,and cell apoptosis in the liver.During liver regeneration,hepatocyte proliferation is affected by Ca2+ mobilization agonist insulin,which regulates hepatocyte proliferation by influencing nuclear Ca2+.In addition,mitochondrial Ca2+ regulates hepatocyte proliferation by inhibiting apoptosis.Chronic viral hepatitis is associated with increased permeability of liver cell membranes,resulting in elevated levels of cytoplasmic calcium.The virus can enhance its replication by regulating the calcium-signaling pathway.This review explores the relationship between Ca2+ signaling in hepatocytes and liver regeneration and various liver diseases.
关键词
钙离子/肝脏再生/病毒性肝炎/非酒精性脂肪肝病Key words
Ca2+/Liver regeneration/Viral hepatitis/Non-alcoholic fatty liver disease引用本文复制引用
基金项目
心脑血管疾病防治教育部重点实验室开放课题(XN201931)
赣州市指导性科技计划项目(GZ2018ZSF003)
赣南医学院博士科研启动项目(QD201802)
研究生创新专项资金(YC2022-X013)
出版年
2024
国家科技期刊平台
NSTL
万方数据