脐带间充质干细胞治疗椎间盘退变研究进展
Research progress in the treatment of intervertebral disc degeneration with umbilical cord mesenchymal stem cells
张学良 1冉兵 2钟瑞丹 1叶军明3
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一附属医院疼痛科
- 3. 赣南医科大学,江西 赣州 341000
- 折叠
摘要
近年来腰背痛患者越来越多,且呈现年轻化趋势,研究发现腰背痛的重要原因之一是椎间盘退变.脐带间充质干细胞(Umbilical cord mesenchymal stem cells,UCMSCs)因具有自我更新能力、多向分化潜能、归巢及免疫调节特性,被广泛用于组织修复再生.UCMSCs移植到椎间盘后可分化为髓核样细胞,合成和分泌蛋白聚糖、Ⅱ型胶原等髓核细胞外基质成分或分泌免疫调节因子,从而修复椎间盘退变,是髓核退变和修复的潜力细胞之一.本文就脐带间充质干细胞在治疗椎间盘退变的研究进展进行综述,以期为后续相关临床研究提供参考.
Abstract
In recent years,the number of patients with low back pain is increasing and the morbidity age assumes the youth-oriented.It has been found that one of the important causes of low back pain is intervertebral disc degeneration.Umbilical cord mesenchymal stem cells(UCMSCs)are widely used in tissue repair and regeneration research because of their self-renewal ability,multidirectional differentiation potential,homing,and immunomodulatory properties.UCMSCs can differentiate into myeloid cells after transplantation into intervertebral discs,synthesize and secrete extracellular matrix components of the nucleus pulposus such as proteoglycan and type Ⅱ collagen,or secrete immunomodulatory factors to repair disc degeneration,and are one of the potential cells for nucleus pulposus degeneration and repair.It is one of the potential cells for medullary degeneration and repair.This paper reviews the research progress of UCMSCs in the treatment of intervertebral disc degeneration,with the aim of providing a reference for subsequent relevant clinical studies.
关键词
脐带间充质干细胞/椎间盘退变/外泌体/修复再生Key words
Umbilical cord mesenchymal stem cells/Intervertebral disc degeneration/Exosome/Repair and regenerate引用本文复制引用
基金项目
赣南医学院研究生创新专项资金项目(YC2022-X008)
出版年
2024
国家科技期刊平台
NSTL
万方数据