JAK/STAT通路介导椎间盘髓核细胞凋亡的研究进展
Advances of JAK/STAT signaling pathway mediating apoptosis of nucleus pulposus cell in intervertebral disc degeneration
易军 1姬广林2
作者信息
- 1. 赣南医科大学第一临床医学院
- 2. 赣南医科大学第一附属医院骨科,江西 赣州 341000
- 折叠
摘要
椎间盘退变(Intervertebral disc degeneration,IDD)是一种与年龄相关的退行性疾病.近年来,IDD的发病率逐年升高,已成为全球关注的公共卫生问题.髓核细胞作为椎间盘内的主要细胞,其凋亡是椎间盘发生退变的重要病理基础之一.研究表明Janus激酶(Janus kinase,JAK)/信号转导子及转录激活因子(Signal transducer and activator of transcriptor,STAT)信号途径与髓核细胞凋亡过程联系密切.本文就JAK/STAT信号通路介导的椎间盘髓核细胞凋亡的研究进展及以JAK/STAT信号通路为潜在治疗靶点进行综述,以期为IDD的治疗提供参考.
Abstract
Intervertebral disc degeneration(IDD)is an age-related degenerative disease.In recent years,the incidence of IDD has been increasing year by year.It has become a public health problem of global concern.Apoptosis of nucleus pulposus cells,as the main cells in the intervertebral disc,is one of the important pathological bases of disc degeneration.Studies have shown that the Janus kinase(JAK)/signal transducer and activator of the transcriptor(STAT)signaling pathway is closely associated with the apoptotic process of the nucleus pulposus.This paper reviews the progress of JAK/STAT signaling pathway-mediated apoptosis in intervertebral discs and the potential therapeutic targets of the JAK/STAT signaling pathway in order to provide new research leads for the treatment of IDD.
关键词
JAK/STAT信号通路/髓核细胞/凋亡/椎间盘退变Key words
JAK/STAT signaling pathway/Nucleus pulposus cell/Apoptosis/Intervertebral disc degeneration引用本文复制引用
基金项目
江西省卫生健康委科技项目(SKJP220211236)
江西省卫生健康委科技项目(SKJP220210619)
江西省卫生健康委科技项目(SKJP220210621)
赣南医学院度科技创新特色建设团队课题(2020)(TS202002)
出版年
2024
国家科技期刊平台
NSTL
万方数据