胰岛素泵在糖尿病合并结直肠癌术后全肠外营养支持中的应用
Application of insulin pump in total parenteral nutrition support for patients with diabetes complicated with colorectal cancer
梁玮秦 1刘小芳 1李石梅 1陈小波2
作者信息
- 1. 赣南医科大学第一附属医院康复医学科
- 2. 赣南医科大学第一附属医院康复医学科;赣南医科大学第二附属医院中医科,江西 赣州 341000
- 折叠
摘要
目的:探讨胰岛素泵持续皮下胰岛素输注在糖尿病合并结直肠癌术后全肠外营养支持中的应用效果.方法:选择结直肠癌术后行全肠外营养治疗(Total parenteral nutrition,TPN)的2型糖尿病患者64例,随机分成胰岛素泵持续皮下输注人胰岛素(胰岛素泵组)和人胰岛素微量注射泵持续静脉泵入(静脉泵组).分别监测2组患者葡萄糖目标范围内时间(Time in range,TIR)、葡萄糖高于目标范围时间(Time above range,TAR)、葡萄糖低于目标范围时间(Time below range,TBR)、平均血糖波动幅度(Mean blood glucose fluctuation amplitude,MAGE)、低血糖发生情况.结果:胰岛素泵组TIR值高于静脉泵组[(76.72±8.54)%vs(72.12±8.34)%],差异有统计学意义(P＜0.05);胰岛素泵组TBR值低于静脉泵组[(13.72±5.28)%vs(16.72±5.00)%],差异有统计学意义(P＜0.05);胰岛素泵组MAGE较静脉泵组血糖波动更小[(2.83±1.06)mmol·L-1 vs(3.39±1.06)mmol·L-1],差异有统计学意义(P＜0.05);2组TAR值差异无统计学意义(P＞0.05);2组患者低血糖发生事件因样本量太小,无比较意义.结论:胰岛素泵用于控制糖尿病合并结直肠癌术后TPN患者血糖与静脉泵注胰岛素相比,TIR值更好,血糖更加平稳.
Abstract
Objective:To investigate the effect of continuous subcutaneous insulin infusion with insulin pump in total parenteral nutrition support for patients with diabetes after colorectal cancer surgery.Methods:A total of 64 patients with type 2 diabetes who received total parenteral nutrition(TPN)after colorectal cancer surgery were randomly divided into two groups:continuous subcutaneous insulin infusion(insulin pump group)and continuous intravenous insulin infusion(intravenous pump group).Monitoring was done about the glucose target time(TIR),glucose above target range time(TAR),glucose below target range time(TBR),mean blood glucose fluctuation amplitude(MAGE),and incidence of hypoglycemia in two groups of patients.Results:The TIR value of the insulin pump group was higher than that of the venous pump group[(76.72±8.54)%vs(72.12±8.34)%],and the difference was statistically significant(P＜0.05);The TBR value of the insulin pump group was lower than that of the venous pump group[(13.72±5.28)%vs(16.72±5.00)%],and the difference was statistically significant(P＜0.05);The MAGE of the insulin pump group had smaller blood glucose fluctuations compared to the venous pump group[(2.83±1.06)mmol·L-1 vs(3.39±1.06)mmol·L-1],and the difference was statistically significant(P＜0.05);There was no statistically significant difference in TAR values between the two groups(P＞0.05).There was no comparative significance of the occurrence of hypoglycemia between the two groups due to the small sample size.Conclusion:Compared with intravenous infusion of insulin,the TIR value of insulin pump used to control the blood sugar of TPN patients with diabetes complicated with colorectal cancer is better and the blood sugar is more stable.
关键词
胰岛素泵/葡萄糖目标范围内时间/血糖波动/全肠外营养Key words
Insulin pump/Time within the target range of glucose/Blood glucose fluctuations/Total parenteral nutrition引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据