Aortic dissection is the most common cardiovascular disease leading to death.It is critical and progresses rapidly.The main pathogenic factors include cytological factors and clinical disease factors.But the molecular mechanism leading to its pathogenesis is still unclear.In recent years,with the development of molecular biology,due to the better understanding of aortic cells and molecular biology,more and more studies are inclined to the molecular mechanism of aortic dissection.The abnormal composition of extracellular matrix proteins in the middle layer of the aortic wall and the destruction of the extracellular matrix break the balance mechanism of the aortic wall,leading to physiological changes in the aorta,which in turn causes the formation of aortic dissection.To understand the molecular mechanism of protein in the formation of aortic dissection,so as to influence the formation and progression of aortic dissection by means of human intervention is important.This review focuses on the research progress of protein molecular mechanism of aortic dissection.
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