Cardiovascular disease(CVD)is the leading cause of death in China.Atherosclerosis,cardiomyocyte apoptosis,myocardial hypertrophy and fibrosis are the main pathological processes of CVD.Gene epigenetic modification,especially DNA methylation,plays an important role in CVD.Studies have suggested that TET translocation methylcytosine dioxygenase 2(TET2)is involved in gene epigenetic regulation,and TET2 plays an important role in the pathogenesis of CVD.TET2 can regulate heart development,ameliorate endothelial cell dysfunction during atherosclerosis,regulate phenotypic transformation of vascular smooth muscle cells,and inhibit immune inflammatory response,myocardial apoptosis,myocardial hypertrophy and fibrosis.This article reviews the latest research on TET2 in CVD.
维普
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