Objective:To study the application effect of hole-free two-point seat belt in hyperbaric oxygen therapy for agitated patients.Methods:A total of 83 cases of agitated patients who received hyperbaric oxygen therapy from January 2019 to January 2022 were selected.They were divided into two groups according to the time of admission to the chamber:two-point safety belt group(41 cases),in the flat car admission therapy using the flat car admission therapy with two no-punching two-point safety belts reinforced in the upper stainless steel frame and the card slot,and the traditional flat car admission therapy group(traditional group,42 cases).The number of oxygen mask removals,the number of falls from the trolley,the adherence to hyperbaric oxygen therapy,the comfort level of the family members accompanying the patients,and the satisfaction level with the hospital between the two groups were compared.Results:The median number of oxygen mask removals and the number of falls in the two-point harness group were fewer than those of the traditional group,with statistical significant(P<0.05).In the two-point harness group,the total compliance rate of family members accompanying the cabin to the patient's hyperbaric oxygen therapy was higher than that of the traditional group(P<0.05),and the comfort score and the total satisfaction rate with the hospital were higher than those of the traditional group(P<0.05).Conclusion:The hole-free two-point safety belt can reduce the number of times of removing the oxygen mask during hyperbaric oxygen therapy in agitated patients,improve the effect of oxygen intake,improve the comfort of the patients,and enhance the adherence to hyperbaric oxygen therapy by the family members accompanying the cabin.